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METABOLIC CORE

METABOLIC CORE
代谢核心
批准号：
8016442
负责人：
JACOB E FRIEDMAN
金额：
$22.38万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-08-01 至 2015-07-31
来源：
https://reporter.nih.gov/project-details/8016442
关键词：
1-Phosphatidylinositol 3-KinaseAnimalsApplications GrantsBiological AssayBudgetsCancer CenterCell NucleusCellsCellular AssayChargeClinicalCollaborationsColoradoComputer softwareConsultConsultationsCore FacilityCost SavingsDiabetes MellitusDiseaseElectrophoresisEquipmentExposure toFatty acid glycerol estersFloorFundingGene ExpressionGenus HippocampusGrantHistocompatibility TestingHormonesHumanInflammationInflammatory ResponseInsulinInsulin ResistanceInvestigationLaboratoriesLinkLiverMalignant NeoplasmsMeasuresMetabolicMetabolismMitochondriaMolecularMusMuscleNutritional StudyObesityPeridermPhosphorylationRattusReadingReagentReportingResearchResearch PersonnelRodentScientistServicesSheepSignaling ProteinTechniquesTimeTranslationsU-Series Cooperative AgreementsUnited States National Institutes of HealthUniversitiesWeight GainWestern Blottingadipokinesanimal databaseclinical practicecostcytokinedesignenergy balanceextracellularfetalinstrumentinsulin sensitivityinsulin signalinginterestlipid metabolismmembermolecular arraynutritionreceptorresearch studytime use

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中文摘要
翻译
代谢核心实验室的总体主题是支持胰岛素抵抗，肥胖， 和炎症的关系。Metabolic Core提供胰岛素信号传导、激素测定、qPCR、胰岛素钳夹（小鼠、大鼠）以及根据研究者需求定制的细胞因子和脂肪因子的基于细胞的测定的咨询和分析。在过去的资助期间，代谢核心已经开发了基于多重细胞因子分析的专业知识。最近，代谢核心获得了NIH的资助，购买了Seahorse XF 24 -3细胞外通量分析仪，使我们能够开始询问线粒体功能。
英文摘要
The overall theme of the Metabolic Core lab is to support investigation of insulin resistance, obesity, and inflammation from a cellular/molecular perspective. The Metabolic Core provides consultation and analysis of insulin signaling, hormone assays, qPCR, insulin clamping (mice, rats), and cell based assays of cytokines and adipokines tailored to the investigators needs. Over the last grant period the Metabolic Core has developed expertise in multiplex based cytokine analysis. Most recently the Metabolic Core received NIH funding to purchase a Seahorse XF24-3 extracellular flux analyzer to allow us to begin to interrogate mitochondrial function.
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