Drosophila Aging Core

果蝇衰老核心：Scott Pletcher，主任 发展援助委员会将满足三大类用户的需要。(1)它将提供咨询，技术援助和专门的设施，果蝇专家新的老化研究。例如，这样的用户可能是果蝇发育或肌肉生物学或昼夜节律的专家，他希望在衰老的背景下评估感兴趣的突变体或药物。(2)它将与经验丰富的果蝇学家进行辅导和合作，这些专家是刚开始研究果蝇的，他们现在希望利用果蝇的遗传潜力来测试分子假设或筛选具有特定特性的突变体或药物。(3)它将提供高度专业化的协议和设备，以支持对衰老苍蝇的复杂研究，这些研究在更短的时间内很难进行。 先进的设施。DAC将特别支持依赖于营养和气味操作，高通量功能测定和器官特异性功能测试的合作，这些测试很少有个别实验室可以收集，但适用于国家或区域资源。

Drosophila Aging Core: Scott Pletcher, Director The DAC will serve the needs of three broad classes of users. (1) It will provide advice, technical assistance, and specialized facilities to Drosophila experts new to aging research. Such a user might, for example, be an expert on Drosophila development or muscle biology or circadian rhythmicity who wishes to evaluate mutants or drugs of interest in the context of aging. (2) It will tutor and collaborate with experienced biogerontologists, new to work on flies, who now wish to exploit the genetic potential of Drosophila to test molecular hypotheses or screen for mutants or drugs with specific properties of interest. (3) It will provide highly specialized protocols and equipment to support sophisticated studies of aging flies that would be difficult to conduct in less sophisticated facilities. The DAC will in particular support collaborations that depend on nutrient and odor manipulations, high throughput functional assays, and tests for organ-specific function that few individual laboratories can muster but that are appropriate for a national or regional resource.