3D SAP-EPI FOR USE IN T1- & SUSCEPTIBILITY-WEIGHTED IMAGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 用于需要快速成像的几种对比机制的标准回波平面成像（EPI）的主要好处是其“快照”功能，允许在几个方向（弥散加权成像[DWI]）、时间帧和/或平均值上重新对齐单独的EPI图像。 然而，单次激发（ss）-EPI中存在的失真仍然是该技术在临床中进步的最引人注目的损害。 EPI中沿相位编码方向的每像素沿着极低带宽也导致非共振伪影（例如水脂移位、磁化率伪影、涡流失真和B 0移位伪影）和T2* 诱导模糊的发展。为了加速k空间遍历，已经提出了交织EPI，但是其对运动相关伪影的敏感性是众所周知的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major benefit of standard echo-planar imaging (EPI) used for several contrast mechanisms requiring fast imaging is its 'snapshot' capability, which allows one to realign separate EPI images over several directions (diffusion-weighted imaging [DWI]), temporal frames, and/or averages. However, the distortions present in single-shot (ss)-EPI have remained the single most compelling detriment to the advance of this technique in the clinics. The extremely low bandwidth per pixel along the phase-encoding direction in EPI also leads to the development of off-resonance artifacts (e.g. water-fat shift, susceptibility artifacts, eddy current distortions, and B0 shift artifacts) and T2* induced blurring. To speed up k-space traversal, interleaved EPI has been proposed but its sensitivity to motion-related artifacts is well known.