STRUCTURE AND MECHANISM OF YAET
STRUCTURE AND MECHANISM OF YAET
批准号:
8170229
负责人:
Marcelo C. Sousa
金额:
$0.1万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-02-28
关键词:
AntibioticsC-terminalCell WallComplexComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentFundingGrantInstitutionMembraneMembrane ProteinsN-terminalProteinsResearchResearch PersonnelResourcesSourceStructureUnited States National Institutes of Healthbeta barrelbeta-Lactamsperiplasmpolypeptide
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This project is focused on determining the structure of the YaeT protein, which is the central component of the YaeT complex responsible for insertion of proteins in the bacterial outer membrane. Interfering with this mechanism of Outer Membrane Protein insertion would be an effective strategy for antibiotic development; much like beta-lactams are effective by inhibiting cell wall synthesis. YaeT consists of a C-terminal beta-barrel embedded in the outer membrane, and an N-terminal periplasmic domain containing five copies of so-called POTRA (polypeptide-transport-associated) sequence motifs. We have determined the crystal structure of a periplasmic YaeT fragment containing 4 POTRA domains.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mechanism of Transport and Folding of Outer Membrane Proteins
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批准号:8088429
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财政年份:2010
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负责人:Marcelo C. Sousa
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依托单位:
Transport and Insertion of Outer Membrane Proteins
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批准号:8289840
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项目类别:
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资助金额:$37.08万
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财政年份:2009
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负责人:Marcelo C. Sousa
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依托单位:
Transport and Insertion of Outer Membrane Proteins
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批准号:7565628
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Molecular Mechanism of Retinal Guanylate Cyclase Activation by GCAPs
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批准号:8065962
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项目类别:
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资助金额:$28.4万
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财政年份:2009
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负责人:Marcelo C. Sousa
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依托单位:
Transport and Insertion of Outer Membrane Proteins
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批准号:7842620
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项目类别:
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资助金额:$37.04万
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财政年份:2009
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负责人:Marcelo C. Sousa
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依托单位:
Molecular Mechanism of Retinal Guanylate Cyclase Activation by GCAPs
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批准号:7653926
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项目类别:
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Transport and Insertion of Outer Membrane Proteins
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批准号:8417662
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项目类别:
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资助金额:$34.84万
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依托单位:
Transport and Insertion of Outer Membrane Proteins
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批准号:8603830
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项目类别:
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资助金额:$37.04万
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财政年份:2009
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负责人:Marcelo C. Sousa
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依托单位:
Molecular Mechanism of Retinal Guanylate Cyclase Activation by GCAPs
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批准号:7805456
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项目类别:
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资助金额:$29.6万
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财政年份:2009
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依托单位:
Mechanism of Enzymes Mediating Resistance in Pseudomonas
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批准号:6903464
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项目类别:
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资助金额:$29.33万
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财政年份:2004
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负责人:Marcelo C. Sousa
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依托单位:
Mechanism of Enzymes Mediating Resistance in Pseudomonas
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批准号:7080419
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项目类别:
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资助金额:$28.63万
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财政年份:2004
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负责人:Marcelo C. Sousa
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依托单位:
Mechanism of Enzymes Mediating Resistance in Pseudomonas
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批准号:6809163
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项目类别:
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资助金额:$28.04万
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财政年份:2004
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负责人:Marcelo C. Sousa
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依托单位:
Mechanism of Enzymes Mediating Resistance in Pseudomonas
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批准号:7245841
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项目类别:
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资助金额:$27.78万
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财政年份:2004
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负责人:Marcelo C. Sousa
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依托单位:
Mechanism of Enzymes Mediating Resistance in Pseudomonas
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批准号:7451053
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项目类别:
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资助金额:$27.24万
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财政年份:2004
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负责人:Marcelo C. Sousa
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依托单位:
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批准年份:2012
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