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ACEK, A BIFUNCTIONAL KINASE/PHOSPHATASE, AND ITS COMPLEX WITH SUBSTRATE

ACEK, A BIFUNCTIONAL KINASE/PHOSPHATASE, AND ITS COMPLEX WITH SUBSTRATE
ACEK,一种双功能激酶/磷酸酶及其与底物的复合物
批准号:
8170261
负责人:
ZONGCHAO JIA
金额:
$0.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-02-28

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Acek is a bifunctional kinase and phosphatase, which regulates isocitrate dehydrogenase (IDH) involved in a bypass of Krebs? cycle. This was the first phosphorylation system to be identified in bacteria, and is one of the only two known Ser/Thr phosphorylation systems. AceK may possess a novel structural fold and the structure of Acek may reveal the structural basis of molecular switch between kinase and phosphatase within a single protein. Furthermore, we have recently obtained a complex crystal between Acek and IDH, which may well be the first kinase complex structure with protein substrate. This complex structure will shed new lights on the substrate recognition and activity regulation.
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STRUCTURAL STUDIES OF CANCER-RELATED PROTEINS
  • 批准号:
    8363515
  • 项目类别:
  • 资助金额:
    $1.76万
  • 财政年份:
    2011
  • 负责人:
    ZONGCHAO JIA
  • 依托单位:
STRUCTURAL STUDIES OF CANCER-RELATED PROTEINS
  • 批准号:
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  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2010
  • 负责人:
    ZONGCHAO JIA
  • 依托单位:
STRUCTURAL STUDIES OF CANCER-RELATED PROTEINS
  • 批准号:
    7955539
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2009
  • 负责人:
    ZONGCHAO JIA
  • 依托单位:
STRUCTURE DETERMINATION OF HALOGENASE CMLS
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  • 项目类别:
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  • 资助金额:
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  • 批准年份:
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  • 负责人:
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  • 依托单位:
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  • 批准号:
    11102131
  • 项目类别:
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  • 资助金额:
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  • 批准年份:
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  • 负责人:
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