课题基金 / 基金详情

STRUCTURE-FUNCTION STUDIES OF MITOCHONDRIA

STRUCTURE-FUNCTION STUDIES OF MITOCHONDRIA
线粒体的结构功能研究
批准号:
8168578
负责人:
WILLIAM James CRAIGEN
金额:
$2.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-01-15 至 2010-12-31

项目摘要

项目成果

WILLIAM James CRAIGEN的其他基金

相关文献

中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to provide preliminary data on structure-function aspects of mitochondria, with a specific focus on the mitochondrial nucleoid, a mtDNA-protein structure that is considered the basis for mitochondrial DNA segregation. As a preliminary study we will partially purify mitochondria from mouse tissues in both wildtype and mutant strains lacking various mitochondrial components. We propose to examine brain mitochondria from a mouse strain that lacks succinyl CoA ligase (SUCLA2), which in yeast has been assigned to the nucleoid and when mutated in humans leads to mtDNA depletion, suggesting a similar role in mammalian nucleoids. A second strain of interest are mice lacking VDACs (Voltage-dependent Anion Channels), the main channel pathway.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
A novel recessive genetic screen for mitochondrial phenotypes in mammalian cells
  • 批准号:
    7787228
  • 项目类别:
  • 资助金额:
    $19.19万
  • 财政年份:
    2010
  • 负责人:
    WILLIAM James CRAIGEN
  • 依托单位:
A novel recessive genetic screen for mitochondrial phenotypes in mammalian cells
  • 批准号:
    8018610
  • 项目类别:
  • 资助金额:
    $23.03万
  • 财政年份:
    2010
  • 负责人:
    WILLIAM James CRAIGEN
  • 依托单位:
GLUCOSE KINETICS IN SUBJECTS WITH MELAS SYNDROME
  • 批准号:
    8356751
  • 项目类别:
  • 资助金额:
    $1.15万
  • 财政年份:
    2010
  • 负责人:
    WILLIAM James CRAIGEN
  • 依托单位:
The role of creatine in health and disease
  • 批准号:
    7348098
  • 项目类别:
  • 资助金额:
    $20.03万
  • 财政年份:
    2008
  • 负责人:
    WILLIAM James CRAIGEN
  • 依托单位: