MICRODIFFRACTION AT THE NE-CAT BEAMLINES

NE-CAT 光束线上的微衍射

• 批准号: 8169219
• 负责人: STEPHEN COPLAN HARRISON
• 金额: $ 5.93万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169219
• 关键词: Communities; Computer Retrieval of Information on Scientific Projects Database; Dimensions; Equipment; Felis catus; Funding; Goals; Grant; Institution; Methods; Research; Research Personnel; Resources; Roentgen Rays; Sampling; Secure; Source; Structure; United States National Institutes of Health; beamline; meetings; operation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Due to increasing demand from our user community to be able carry out diffraction experiments with crystals smaller than 20-30 microns, during early 2007 the Resource implemented a microdiffraction facility at the 24-ID-E beamline. With that, we were able to deliver stable X-ray beams as small as 5 microns, which can be tailored to dimensions of the samples in order to reduce scattering contamination and backgrounds. This operating installation resulted in meeting one of our major Core 1 goals of providing the first such microdiffraction facility in the US. Also, this has resulted in some unique structures, which otherwise would not have been possible. The microdiffraction experiments at 24-ID-E beam-line were so successful and popular that our user community wanted us to replicate the exact same capability on our tunable beamline 24-ID-C as well. With the support of our core collaborators and HHMI investigators (S.C. Harrison, D. Eisenberg and E. Gouaux), we were able to secure funding (equipment grant to SCH) for a second MD2 for installation on 24-ID-C. During early 2009, 24-ID-C was outfitted with an MD2, similar to the one on 24-ID-E. While the first year of Core 1 research was spent on set-up, commissioning and user operations, during the second year we concentrated on developing methods for practical use of microdiffraction and enhancement of the microdiffraction capability.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于我们的用户社区越来越多地要求能够对小于20-30微米的晶体进行衍射实验，在2007年初，资源公司在24-ID-E光束线上安装了一个微衍射设施。有了这个，我们能够提供小到5微米的稳定X射线束，它可以根据样品的尺寸进行定制，以减少散射污染和背景。这一运行安装导致我们的核心1的主要目标之一，提供在美国的第一个这样的微衍射设施。此外，这还导致了一些独特的结构，否则是不可能的。24-ID-E光束线的微衍射实验非常成功和受欢迎，我们的用户社区希望我们在我们的可调谐光束线24-ID-C上也复制完全相同的功能。在我们的核心合作者和HHMI调查人员（S.C.哈里森，D。Eisenberg和E. Gouaux），我们能够获得资金（向SCH提供设备赠款），用于在24-ID-C上安装第二台MD 2。在2009年初，24-ID-C装备了一架类似于24-ID-E的MD 2。Core 1研究的第一年用于设置、调试和用户操作，而在第二年，我们专注于开发实际使用微衍射和增强微衍射能力的方法。