ARCHAEAL RNA LIGASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在生活中，参与RNA剪接的两条不同的RNA连接途径可以被精确定位。酵母型和动物/古生物型连接途径。虽然人类主要利用动物型RNA连接途径，但许多病原体如莱氏原虫和锥虫依赖于酵母型tRNA连接途径。因此，酵母型tRNA连接酶是开发治疗几种热带疾病药物的良好靶点。 对古生菌RNA连接酶的鉴定应该启发对人类tRNA连接酶的鉴定，文献中已将其描述为非常不稳定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In life two different RNA ligation pathways involved in RNA splicing can be pinpointed. The yeast type and the animal/archaeal type ligation pathway. While human mainly utilize the animal type RNA ligation pathway, many pathogens like Leihsmania and Trypanosome rely on the yeast-type tRNA ligation pathway. Hence the yeast type tRNA ligase is a good target to develop a medication against several tropical diseases. Identification of the archaeal RNA ligase should inspire the identification of the human tRNA ligase which has been described in literature as very unstable.