HIGHLY CYTOTOXIC IRON(II) COMPLEXES WITH PENTADENTATE PYRIDYL LIGANDS

具有五齿吡啶基配体的高细胞毒性铁 (II) 络合物

• 批准号: 8171429
• 负责人: Chun-Tao Che
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171429
• 关键词: Apoptotic; Cell Death; Cell Line; Cervical; Cisplatin; Cleaved cell; Complex; Computer Retrieval of Information on Scientific Projects Database; Exhibits; Funding; Grant; Human; In Vitro; Institution; Iron; Ligands; Malignant Epithelial Cell; Oxidants; Physiological; Reducing Agents; Research; Research Personnel; Resources; Series; Source; United States National Institutes of Health; cytotoxic; cytotoxicity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin. 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmidDNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在生理条件下，具有戊酸吡啶基配体的铁（II）配合物1a和2是稳定的，并且比顺铂表现出更高的细胞毒性朝向一系列人类癌细胞系。 1a可以显着提高细胞内氧化剂水平，在体外切割超冰的质粒体，而无需添加还原剂并诱导凋亡细胞死亡 流式细胞仪研究中观察到的人类宫颈上皮细胞癌细胞（HELA）。