课题基金 / 基金详情

INDENTIFCATION OF PROTEIN THAT INTERACT WITH DHDAC4

INDENTIFCATION OF PROTEIN THAT INTERACT WITH DHDAC4
与 DHDAC4 相互作用的蛋白质的鉴定
批准号：
8171442
负责人：
MARC R MONTMINY
金额：
$0.24万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-09-01 至 2011-08-31
来源：
https://reporter.nih.gov/project-details/8171442
关键词：
Computer Retrieval of Information on Scientific Projects DatabaseDrosophila genusFundingGene ExpressionGrantHDAC4 geneInstitutionMetabolicMuscle functionProteinsResearchResearch PersonnelResourcesRoleSignal TransductionSourceTissuesUnited States National Institutes of Healthnovel

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 IIa类HDAC优先在肌肉中表达，在肌肉中它们作为基因表达的信号依赖抑制物发挥作用。为了了解它们在果蝇代谢组织中的作用，我们的目标是在果蝇中鉴定新的HDAC4相互作用蛋白。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Class IIa HDACs are preferentially expressed in muscles, where they function as a signal-dependent repressors of gene expression. To understand their role in metabolic tissues in Drosophila, we aimed to identify novel interaction proteins of HDAC4 in Drosophila.
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