ASSOCIATION OF THE ESTROGEN RECEPTOR WITH NUCLEAR PROTEINS

雌激素受体与核蛋白的关联

• 批准号: 8171273
• 负责人: Ann Nardulli
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171273
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; DNA Binding; Estrogen Receptors; Estrogens; Funding; Genes; Genetic Transcription; Grant; Hormones; Institution; Nuclear Protein; Nuclear Proteins; Proteins; Research; Research Personnel; Resources; Response Elements; Source; United States National Institutes of Health; interest; novel; receptor binding

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binding of the estrogen receptor (ER) to hormone and the estrogen response element (ERE) initiates transcription of estrogen responsive genes. However, it has become clear that the ER does not act in isolation but requires the participation of numerous coregulatory proteins. We are interested in identifying novel coregulatory proteins that interact with the DNA-bound ER and in determining whether the ERE sequence alters the association of proteins with the ERE-bound receptor.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 雌激素受体（ER）与激素和雌激素反应元件（ERE）的结合启动雌激素反应基因的转录。然而，很明显，内质网并不是孤立地发挥作用，而是需要许多共调节蛋白的参与。我们感兴趣的是鉴定与 DNA 结合 ER 相互作用的新型共调节蛋白，并确定 ERE 序列是否改变蛋白质与 ERE 结合受体的关联。