ASSOCIATION OF THE ESTROGEN RECEPTOR WITH NUCLEAR PROTEINS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 雌激素受体（ER）与激素和雌激素反应元件（ERE）的结合启动雌激素反应基因的转录。然而，已经清楚的是，ER并不是孤立地起作用，而是需要许多共调节蛋白的参与。我们感兴趣的是确定新的辅调节蛋白，与DNA结合的ER相互作用，并在确定是否ERE序列改变与ERE结合受体的蛋白质的协会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binding of the estrogen receptor (ER) to hormone and the estrogen response element (ERE) initiates transcription of estrogen responsive genes. However, it has become clear that the ER does not act in isolation but requires the participation of numerous coregulatory proteins. We are interested in identifying novel coregulatory proteins that interact with the DNA-bound ER and in determining whether the ERE sequence alters the association of proteins with the ERE-bound receptor.