ASSOCIATION OF THE ESTROGEN RECEPTOR WITH NUCLEAR PROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 雌激素受体(ER)与激素和雌激素反应元件(ERE)结合，启动雌激素反应基因的转录。然而，已经很清楚的是，内质网并不是孤立地发挥作用，而是需要许多共同调节蛋白的参与。我们感兴趣的是识别与DNA结合的ER相互作用的新的共调节蛋白，以及确定ERE序列是否改变了蛋白质与ERE结合受体的联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binding of the estrogen receptor (ER) to hormone and the estrogen response element (ERE) initiates transcription of estrogen responsive genes. However, it has become clear that the ER does not act in isolation but requires the participation of numerous coregulatory proteins. We are interested in identifying novel coregulatory proteins that interact with the DNA-bound ER and in determining whether the ERE sequence alters the association of proteins with the ERE-bound receptor.