Dynamic Structure of the Nuclear Hormone Receptors

核激素受体的动态结构

• 批准号: 7673054
• 负责人: Ann Nardulli
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673054
• 关键词: American; Area; Attention; Biology; Biophysics; Cells; Collaborations; Communication; DNA; Development; Disease; Environment; Family; Fostering; Gene Expression; Goals; Homeostasis; Investigation; Kinetics; Ligands; Metabolic; Metabolism; Methods; Molecular; Movement; Nature; Nuclear Hormone Receptors; Nuclear Receptors; Organism; Physiological; Physiological Processes; Physiology; Play; Protein Biochemistry; Protein Chemistry; Protein Dynamics; Protein Family; Proteins; Reproduction; Research Personnel; Rivers; Role; Scientist; Signaling Protein; Societies; Steroid Receptors; Structure; Structure-Activity Relationship; System; Tissues; Underrepresented Minority; Vermont; Woman; Work; abstracting; activating transcription factor; chromatin remodeling; design; flexibility; insight; meetings; protein structure; receptor; receptor function; receptor structure function; reproductive function; sensor; small molecule; symposium

DESCRIPTION (provided by applicant): Communication among cells is of central importance to multi-cellular organisms. Indeed it could be argued that communication is one of the defining features of multi-cellular organisms, as it allows for cell specialization and cell organization into tissues in a controlled and regulated manner. It has been 20 years since the first steroid receptor cDNAs were cloned, a development that led to the identification of a super-family of ligand-activated transcription factors: the nuclear hormone receptors. Natural ligands for nuclear hormone receptors act as sensors of the intracellular and extra-cellular environment and play crucial roles in development, differentiation, metabolic homeostasis, and reproduction. Considerable progress has been made in our understanding of the structure, mechanisms of action, and biology of this important family of proteins. However, the idea that these receptors have regions of significant structural flexibility that have profound effects on nuclear receptor interactions and function is underappreciated. The goals of the 2009 Federation of American Societies of Experimental Biology (FASEB) Summer Conference on the Dynamic Structure of the Nuclear Hormone Receptors are to (1) bring together experts from the nuclear hormone receptor and protein biochemistry/molecular biophysics fields in order to further our understanding of protein dynamics and methods that could be applied to understand nuclear receptor structure-function relationships, (2) promote discussion and collaboration through sharing new findings on the dynamic nature of nuclear hormone receptors, and (3) foster active participation by young researchers and underrepresented minorities in presenting and discussing their work. The interdisciplinary nature and format of this meeting sets it apart from other meetings held on the nuclear hormone receptors and establishes a forum for open and stimulating discussion on the dynamic nature of this important class of signalling proteins.

描述（由申请人提供）：细胞间的通讯对多细胞生物至关重要。事实上，可以说，通讯是多细胞生物的决定性特征之一，因为它允许细胞特化和细胞组织以一种受控制和调节的方式组成组织。自第一批类固醇受体cdna克隆以来，已经过去了20年，这一进展导致了配体激活转录因子超家族的鉴定：核激素受体。核激素受体的天然配体是细胞内和细胞外环境的传感器，在发育、分化、代谢稳态和繁殖中起着至关重要的作用。我们对这一重要蛋白质家族的结构、作用机制和生物学的理解已经取得了相当大的进展。然而，这些受体具有显著结构灵活性的区域，对核受体的相互作用和功能有深远的影响，这一观点被低估了。2009年美国实验生物学联合会（FASEB）核激素受体动态结构夏季会议的目标是(1)汇集来自核激素受体和蛋白质生物化学/分子生物物理学领域的专家，以进一步了解蛋白质动力学和可用于理解核受体结构-功能关系的方法；(2)通过分享关于核激素受体动态性质的新发现来促进讨论和合作；(3)促进年轻研究人员和未被充分代表的少数群体积极参与介绍和讨论他们的工作。本次会议的跨学科性质和形式使其有别于其他关于核激素受体的会议，并为这类重要信号蛋白的动态性质建立了一个开放和刺激的讨论论坛。