FUNCTION BIRN

功能伯恩

• 批准号: 8171044
• 负责人: STEVEN G POTKIN
• 金额: $ 0.91万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171044
• 关键词: Algorithms; Behavioral; Clinical; Clinical Trials; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Data; Data Set; Databases; Development; Disease; Distributed Databases; Focus Groups; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Grant; Image; Informatics; Institution; Learning; Location; Methods; Patients; Pattern; Phase; Population; Protocols documentation; Research; Research Infrastructure; Research Personnel; Resources; Schizophrenia; Series; Site; Source; Statistical Methods; Structure; System; Technology; United States National Institutes of Health; data mining; flexibility; image processing; knowledge base; meetings; neuroimaging; neuropsychiatry; novel; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of the FBIRN is to develop technology and methods to conduct multisite functional imaging studies, and to produce a knowledge base that would not otherwise be available through single-site imaging studies. The technology includes the development and refinement of multi-site, functional imaging protocols using robust cognitive tasks; the development and refinement of algorithms to reduce inter-site variability; the use of federated, distributed databases and storage; flexible and robust image processing software integrated with these databases and storage infrastructure; tools for data querying across the distributed databases to extract subsets of data from multiple sources; and the development of both classical statistical and data mining methods to reveal the patterns of imaging, clinical, and behavioral data which differentiate important population clusters. To meet this goal, the FBIRN will develop the capacity to conduct a multi-center functional imaging study in a focused group of subjects with a neuropsychiatric disorder, patients with schizophrenia. The lessons learned, the statistical methods developed, and the informatics structure constructed will be generalizable and applicable to a wide variety of clinical investigations. The ability to integrate subsets of clinical, functional imaging, and behavioral datasets from disparate sites to form novel datasets will be assessed in a phased series of developments and optimizations. The overall goal of this proposal is to develop tools to make multi-site fMRI studies a common research practice. Completion of this goal enables researchers to investigate the pathophysiology of complex diseases more thoroughly, through the increased power of large-scale, collaborative neuroimaging studies. When completed, researchers in different fields and physical locations will be able to draw on a common set of tools and database systems not possible at a single site.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 FBIRN的首要目标是开发进行多部位功能成像研究的技术和方法，并建立一个在其他情况下无法通过单部位成像研究获得的知识库。这项技术包括使用稳健的认知任务开发和改进多站点功能成像协议；开发和改进算法以减少站点间的变异性；使用联合、分布式数据库和存储；与这些数据库和存储基础设施集成的灵活而强大的图像处理软件；用于跨分布式数据库的数据查询工具以从多个来源提取数据子集；以及开发经典统计和数据挖掘方法以揭示区分重要人群群的成像、临床和行为数据的模式。为了实现这一目标，FBIRN将发展在一组有神经精神障碍的受试者--精神分裂症患者中进行多中心功能成像研究的能力。所学到的教训，发展的统计方法，以及构建的信息学结构将是可推广的，并适用于各种临床调查。整合来自不同地点的临床、功能成像和行为数据集的子集以形成新数据集的能力将在一系列分阶段的开发和优化中进行评估。这项提议的总体目标是开发工具，使多点功能磁共振研究成为一种常见的研究实践。这一目标的完成使研究人员能够通过大规模、协作的神经成像研究的增加，更彻底地研究复杂疾病的病理生理学。完成后，不同领域和物理位置的研究人员将能够利用一套在单一地点不可能实现的通用工具和数据库系统。