TRANSDISCIPLINARY IMAGING GENETICS CENTER (1 OF 2)(RMI)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 建议的跨学科成像遗传学中心，一个探索性的中心，首要目标是通过促进一个新的学科，称为成像遗传学的发展，以提高我们对健康和疾病的大脑功能的理解。该中心通过组建一个由来自加州大学的专家组成的跨学科团队来实现这一目标。欧文和多伦多大学在基因组学、成像分析、统计方法和互补领域的经验被视为实现这一目标的关键。这些专家在中心顾问和外部咨询委员会的辅助下，在各自领域开发了新的方法。该项目的主要重点是开发结合成像和基因组学的方法。很明显，精神疾病涉及大脑功能障碍，可以通过先进的大脑成像技术可视化。精神疾病以及正常的大脑功能也有遗传成分;因此，必须考虑与大脑发育，精神功能和功能障碍有关的基因。将影像数据与人类基因组计划产生的丰富遗传数据相结合，将增强我们对大脑功能和精神疾病的理解。在我们的初步研究中说明了这种整合的价值，这些研究证明了脑代谢、临床应答和DRD 1等位基因之间的相关性（Potkin et al，2003），以及脑代谢、迟发性运动障碍风险（抗精神病药物治疗的运动副作用）和DRD 3等位基因之间的相关性（Potkin et al，2003 b，Basile et al，2002）。该中心建议通过赞助年度国际研讨会，促进各领域之间的持续对话，并为这一新兴学科制定和实施路线图或工作计划。中心的工作计划将由中心研究人员、其指导委员会、中心顾问和外部咨询委员会之间的跨学科合作指导。指导委员会和外部咨询委员会还负责评估中心的研究进展，提出替代解决方案，并指导中心的整体发展。如果该中心的目标得以实现，新兴的遗传成像领域将被定位为增强对精神疾病，个体差异以及遗传，环境和大脑功能之间相互作用的生物学复杂问题的理解。对这些领域的单独研究提供了关于脑功能障碍的重要启示。然而，它们的结合和相互作用将提供以其他方式无法获得的新知识。如果没有一个集中于单一综合主题的统一中心，这些目标就无法实现。该中心产生的新知识为改善精神疾病的诊断和治疗提供了相当大的希望。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overriding goal of the proposed Transdisciplinary Imaging Genetics Center, an exploratory center, is to enhance our understanding of brain function in health and disease, through facilitation of development of a new discipline, referred to as imaging genetics. The Center does this by assembling an interdisciplinary team of experts from U.C. Irvine and the University of Toronto with experience in genomics, imaging analysis, statistical methods, and complementary areas viewed as key to this goal. These experts, complemented by the Center's consultants and External Advisory Board, have developed novel methods in their respective fields. The major focus of this project is to develop methods for combining imaging and genomics. It is clear that mental illness involves brain dysfunction that can be visualized with advanced brain imaging techniques. Mental illness as well as normal brain function also has a hereditary component; therefore, it is essential that the genes related to aspects of brain development, mental function and dysfunction, be considered. The integration of the imaging data with the rich genetic data resulting from the human genome project will enhance our understanding of brain function and mental illness. The value of this integration is illustrated in our initial studies that demonstrated an association between brain metabolism, clinical response and DRD1 alleles (Potkin at al, 2003), and between brain metabolism, risk of tardive dyskinesia, a motor side-effect on antipsychotic treatment, and DRD3 alleles (Potkin et al 2003b, Basile et al, 2002). The Center proposes the facilitation of an ongoing dialogue among the various fields involved by sponsoring annual international symposia and the development and implementation of a roadmap or work plan for this emerging discipline. The work plan for the Center will be guided by a transdiscipllnary collaboration between the Center investigators, their Steering Committee, the Center consultants, and the External Advisory Board. The Steering Committee and External Advisory Board are also charged with evaluating the Center's research progress and suggesting alternative solutions, as well as guiding the overall development of the Center. If the aims of the Center are achieved, the emerging field of genetic imaging will be positioned to enhance understanding of the biologically complex problem of mental illness, individual differences, and the interplay between genetics, environment, and brain function. Study of these fields individually has provided important revelations regarding brain dysfunction. Their integration and interaction, however, will provide new knowledge that would not be otherwise available. These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness.