TRANSDISCIPLINARY IMAGING GENETICS CENTER (1 OF 2)(RMI)

跨学科成像遗传学中心（2 中的 1）(RMI)

• 批准号: 7955659
• 负责人: STEVEN G POTKIN
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955659
• 关键词: Adverse effects; Alleles; Antipsychotic Agents; Area; Brain; Brain imaging; Charge; Clinical; Collaborations; Complement; Complex; Computer Retrieval of Information on Scientific Projects Database; DRD1 gene; Data; Development; Diagnosis; Discipline; Disease; Environment; Essential Genes; Functional disorder; Funding; Genetic; Genomics; Goals; Grant; Health; Human Genome Project; Image; Image Analysis; Imaging Techniques; Individual Differences; Inherited; Institution; International; Knowledge; Mental disorders; Methods; Modeling; Motor; Positioning Attribute; Research; Research Personnel; Resources; Risk; Solutions; Source; Statistical Methods; Tardive Dyskinesia; United States National Institutes of Health; Universities; Work; brain metabolism; computational anatomy; experience; field study; improved; mental development; novel; response; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overriding goal of the proposed Transdisciplinary Imaging Genetics Center, an exploratory center, is to enhance our understanding of brain function in health and disease, through facilitation of development of a new discipline, referred to as imaging genetics. The Center does this by assembling an interdisciplinary team of experts from U.C. Irvine and the University of Toronto with experience in genomics, imaging analysis, statistical methods, and complementary areas viewed as key to this goal. These experts, complemented by the Center's consultants and External Advisory Board, have developed novel methods in their respective fields. The major focus of this project is to develop methods for combining imaging and genomics. It is clear that mental illness involves brain dysfunction that can be visualized with advanced brain imaging techniques. Mental illness as well as normal brain function also has a hereditary component; therefore, it is essential that the genes related to aspects of brain development, mental function and dysfunction, be considered. The integration of the imaging data with the rich genetic data resulting from the human genome project will enhance our understanding of brain function and mental illness. The value of this integration is illustrated in our initial studies that demonstrated an association between brain metabolism, clinical response and DRD1 alleles (Potkin at al, 2003), and between brain metabolism, risk of tardive dyskinesia, a motor side-effect on antipsychotic treatment, and DRD3 alleles (Potkin et al 2003b, Basile et al, 2002). The Center proposes the facilitation of an ongoing dialogue among the various fields involved by sponsoring annual international symposia and the development and implementation of a roadmap or work plan for this emerging discipline. The work plan for the Center will be guided by a transdiscipllnary collaboration between the Center investigators, their Steering Committee, the Center consultants, and the External Advisory Board. The Steering Committee and External Advisory Board are also charged with evaluating the Center's research progress and suggesting alternative solutions, as well as guiding the overall development of the Center. If the aims of the Center are achieved, the emerging field of genetic imaging will be positioned to enhance understanding of the biologically complex problem of mental illness, individual differences, and the interplay between genetics, environment, and brain function. Study of these fields individually has provided important revelations regarding brain dysfunction. Their integration and interaction, however, will provide new knowledge that would not be otherwise available. These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议的跨学科成像遗传学中心（一个探索性中心）的首要目标是通过促进称为成像遗传学的新学科的发展来增强我们对健康和疾病中大脑功能的理解。该中心通过组建来自加州大学伯克利分校的跨学科专家团队来实现这一目标。欧文和多伦多大学在基因组学、成像分析、统计方法和互补领域拥有丰富的经验，被认为是实现这一目标的关键。这些专家在中心顾问和外部顾问委员会的协助下，在各自领域开发了新颖的方法。该项目的主要重点是开发结合成像和基因组学的方法。显然，精神疾病涉及大脑功能障碍，可以通过先进的大脑成像技术将其可视化。精神疾病和正常的大脑功能也有遗传因素。因此，必须考虑与大脑发育、心理功能和功能障碍相关的基因。将成像数据与人类基因组计划产生的丰富遗传数据相结合将增强我们对大脑功能和精神疾病的理解。这种整合的价值在我们的初步研究中得到了说明，这些研究证明了脑代谢、临床反应和 DRD1 等位基因之间的关联（Potkin 等，2003），以及脑代谢、迟发性运动障碍风险、抗精神病药物治疗的运动副作用和 DRD3 等位基因之间的关联（Potkin 等，2003b，Basile 等，2002）。该中心建议通过主办年度国际研讨会以及为这一新兴学科制定和实施路线图或工作计划，促进所涉及的各个领域之间的持续对话。该中心的工作计划将以中心研究人员、指导委员会、中心顾问和外部咨询委员会之间的跨学科合作为指导。指导委员会和外部顾问委员会还负责评估中心的研究进展并提出替代解决方案，并指导中心的整体发展。如果该中心的目标得以实现，新兴的基因成像领域将有助于增强对精神疾病、个体差异以及遗传学、环境和大脑功能之间相互作用等生物学复杂问题的理解。对这些领域的单独研究提供了有关脑功能障碍的重要启示。然而，它们的整合和相互作用将提供原本无法获得的新知识。如果没有一个专注于单一综合主题的统一中心，这些目标就不可能实现。该中心产生的新知识为改善精神疾病的诊断和治疗带来了巨大的希望。