MULTIMODAL MPET & MMRI IMAGING INSTRUMENTATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们建议将正电子发射断层扫描（PET）和磁共振成像（MRI）模式的最佳功能联合收割机结合在一台仪器中，该仪器将同时记录两种成像模式的数据。此外，我们将开发标记探针，可以在PET和MRI中检测到，以帮助解释复杂的生物过程。该系统将致力于以最高的空间和时间分辨率研究小动物模型系统。我们将构建一个高分辨率、相对高灵敏度的多层muPET扫描仪，集成在定制的7 T/30 cm小动物MR系统中，该系统将同时记录MR和PET图像。通过使用光纤耦合，muPET系统将最小限度地干扰muMR系统，从而能够基本上同时采集高质量的muPET和IJMRI数据，并且空间配准近乎完美。该系统是早期原理验证系统的自然延伸，并且现在接近完成的较新原型动物muPET系统。该系统的基本设计元素已经过测试和演示工作。我们提出的组合系统增加了一些重要的功能，以提高性能和易用性，在体内成像研究。它还首次采用了多切片muPET系统，四个探测器环同时提供七个成像平面，跨越约8 mm的轴向视野，分辨率至少为2 mm。同步muPET/muMRI记录将提供时间和空间分离扫描无法提供的重要相关性（例如，BOLD MRI与FDG PET相比）。融合系统将为muPET研究提供高分辨率解剖参考系统。“配准”muMR图像将用于计算IJPET图像中的散射和衰减，并估计PET扫描中的部分体积误差，从而帮助PET信号的量化。该系统将开辟许多目前独立技术不可能实现的机会，其中包括：药物分布的时间相关IJPET和MRS研究;心脏、CNS和肿瘤细胞代谢。小动物同时进行fMRI和muPET神经受体脑映射研究。使用其PET对应物确认新MRI探头。双PET/MRI标签将允许将MRI数据收集方案“放大”到包含标签的样本区域，以及提供PET和MR图像的精确配准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to combine the best features of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) modalities in a single instrument that will simultaneously record data in both imaging modalities. Moreover, we will develop labeled probes that can be detected in both PET and MRI to aid in the interpretation of complex biological processes. This system will be dedicated to the study of small animal model systems at the highest spatial and temporal resolutions attainable. We will build a high resolution, relatively high sensitivity multi-slice muPET scanner integrated within a customized 7T/30cm small animal MR system that will simultaneously record MR and PET images Through the use of fiber-optic couplings, the muPET system will interfere minimally with the muMR system, enabling high quality muPET and IJMRI data to be acquired essentially simultaneously and in near-perfect spatial registration. This system is a natural extension of earlier proof-of-principle systems and a newer prototype animal muPET system now nearing completion. The basic design elements of the system have been tested and demonstrated to work. The combined system we propose adds a number of important features to improve performance and ease of use for in vivo imaging studies. It also incorporates, for the first time, a multi-slice muPET system, with four detector rings simultaneously providing seven imaging planes, spanning an axial field of view of approximately 8mm, with at least 2mm resolution. Simultaneous muPET/muMRI recordings will provide important correlations not available from temporally and spatially separate scans (e.g. BOLD MRI compared with FDG PET). The melded system will provide high resolution anatomical reference systems for muPET studies The 'in register' muMR images will be used to compute scatter and attenuation in the IJPET images and to estimate partial volume errors in the PET scans, thus aiding quantification of the PET signal. This system will open up a number of opportunities not possible with current independent technologies Among them are: Time correlated IJPET and MRS studies of drug distributions; cardiac, CNS and tumor cell metabolism. Simultaneous fMRI and muPET neuroreceptor brain mapping studies in small animals. Validation of new MRI probes using their PET counterparts. Dual PET/MRI labels will allow for "zooming-in" the MRI data collection scheme to those regions of the specimen containing the label, as well as providing for precise registration of the PET & MR images.