MULTIMODAL MPET & MMRI IMAGING INSTRUMENTATION

多式联运 MPET

• 批准号: 7955657
• 负责人: RUSSELL E JACOBS
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955657
• 关键词: Animal Model; Animals; Biological Models; Biological Process; Brain Mapping; Cardiac; Central Nervous System Neoplasms; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Elements; Fiber Optics; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Institution; Label; Magnetic Resonance Imaging; Metabolism; Modeling; Performance; Positron-Emission Tomography; Research; Research Personnel; Resolution; Resources; Scanning; Scheme; Sensory Receptors; Signal Transduction; Slice; Source; Specimen; System; Technology; Testing; Time; United States National Institutes of Health; Validation; Work; attenuation; computational anatomy; design; detector; drug distribution; imaging modality; imaging probe; improved; in vivo; instrument; instrumentation; neoplastic cell; prototype

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to combine the best features of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) modalities in a single instrument that will simultaneously record data in both imaging modalities. Moreover, we will develop labeled probes that can be detected in both PET and MRI to aid in the interpretation of complex biological processes. This system will be dedicated to the study of small animal model systems at the highest spatial and temporal resolutions attainable. We will build a high resolution, relatively high sensitivity multi-slice muPET scanner integrated within a customized 7T/30cm small animal MR system that will simultaneously record MR and PET images Through the use of fiber-optic couplings, the muPET system will interfere minimally with the muMR system, enabling high quality muPET and IJMRI data to be acquired essentially simultaneously and in near-perfect spatial registration. This system is a natural extension of earlier proof-of-principle systems and a newer prototype animal muPET system now nearing completion. The basic design elements of the system have been tested and demonstrated to work. The combined system we propose adds a number of important features to improve performance and ease of use for in vivo imaging studies. It also incorporates, for the first time, a multi-slice muPET system, with four detector rings simultaneously providing seven imaging planes, spanning an axial field of view of approximately 8mm, with at least 2mm resolution. Simultaneous muPET/muMRI recordings will provide important correlations not available from temporally and spatially separate scans (e.g. BOLD MRI compared with FDG PET). The melded system will provide high resolution anatomical reference systems for muPET studies The 'in register' muMR images will be used to compute scatter and attenuation in the IJPET images and to estimate partial volume errors in the PET scans, thus aiding quantification of the PET signal. This system will open up a number of opportunities not possible with current independent technologies Among them are: Time correlated IJPET and MRS studies of drug distributions; cardiac, CNS and tumor cell metabolism. Simultaneous fMRI and muPET neuroreceptor brain mapping studies in small animals. Validation of new MRI probes using their PET counterparts. Dual PET/MRI labels will allow for "zooming-in" the MRI data collection scheme to those regions of the specimen containing the label, as well as providing for precise registration of the PET & MR images.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们建议将正电子发射断层扫描 (PET) 和磁共振成像 (MRI) 模式的最佳功能结合在一台仪器中，该仪器将同时记录两种成像模式的数据。此外，我们将开发可在 PET 和 MRI 中检测到的标记探针，以帮助解释复杂的生物过程。该系统将致力于以可达到的最高空间和时间分辨率研究小动物模型系统。我们将构建一个高分辨率、相对高灵敏度的多层 muPET 扫描仪，集成在定制的 7T/30cm 小动物 MR 系统中，该系统将同时记录 MR 和 PET 图像。通过使用光纤耦合，muPET 系统将对 muMR 系统的干扰降至最低，从而能够基本上同时且近乎完美地采集高质量的 muPET 和 IJMRI 数据 空间配准。该系统是早期原理验证系统的自然延伸，也是目前即将完成的新型动物 muPET 系统原型。该系统的基本设计元素已经过测试并证明可以工作。我们提出的组合系统增加了许多重要的功能，以提高体内成像研究的性能和易用性。它还首次采用了多切片 muPET 系统，具有四个探测器环，同时提供七个成像平面，横跨约 8 毫米的轴向视场，分辨率至少为 2 毫米。同时 muPET/muMRI 记录将提供时间和空间上独立扫描所无法提供的重要相关性（例如，BOLD MRI 与 FDG PET 相比）。融合系统将为 muPET 研究提供高分辨率解剖参考系统。“对准”muMR 图像将用于计算 IJPET 图像中的散射和衰减，并估计 PET 扫描中的部分体积误差，从而帮助量化 PET 信号。该系统将带来许多当前独立技术无法实现的机会，其中包括： 药物分布的时间相关 IJPET 和 MRS 研究；心脏、中枢神经系统和肿瘤细胞代谢。在小动物中同时进行 fMRI 和 muPET 神经受体脑图谱研究。使用 PET 对应物验证新型 MRI 探头。双 PET/MRI 标签将允许将 MRI 数据收集方案“放大”到包含标签的样本区域，并提供 PET 和 MR 图像的精确配准。