MULTIMODAL MPET & MMRI IMAGING INSTRUMENTATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议将正电子发射断层扫描(PET)和磁共振成像(MRI)模式的最佳功能结合在一台仪器中，以同时记录这两种成像模式的数据。此外，我们将开发可以在PET和MRI中检测到的标记探针，以帮助解释复杂的生物过程。该系统将致力于以可达到的最高空间和时间分辨率研究小动物模型系统。我们将构建一个高分辨率、相对高灵敏度的多层MuPET扫描仪，集成在定制的7T/30 cm小动物MR系统中，通过使用光纤耦合同时记录MR和PET图像，MuPET系统将最大限度地减少对MuMR系统的干扰，使高质量的MuPET和IJMRI数据能够基本上同时采集，并在近乎完美的空间配准中进行。该系统是早期原理验证系统的自然延伸，是即将完成的较新的动物MuPET系统原型。该系统的基本设计元素已经过测试，并演示了其工作原理。我们提出的组合系统增加了许多重要功能，以提高性能和体内成像研究的易用性。它还首次采用了多层MuPET系统，四个探测器环同时提供七个成像平面，横跨大约8 mm的轴向视场，分辨率至少为2 mm。同步的muPET/muMRI记录将提供时间和空间分离扫描所不具备的重要相关性(例如，与FDG PET相比，BOLD MRI)。该融合系统将为MuPET研究提供高分辨率的解剖参照系。“注册”的MuMR图像将用于计算IJPET图像中的散射和衰减，并估计PET扫描中的部分体积误差，从而帮助对PET信号进行量化。该系统将开辟一些目前独立技术无法实现的机会，其中包括：时间相关的IJPET和MRS药物分布研究；心脏、中枢神经系统和肿瘤细胞代谢。小动物的fmri和muPET神经感受器脑图的同步研究。使用其PET对应物验证新的MRI探头。双PET/MRI标签将允许将MRI数据收集方案“放大”到包含标签的样本区域，并提供PET和MR图像的精确配准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to combine the best features of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) modalities in a single instrument that will simultaneously record data in both imaging modalities. Moreover, we will develop labeled probes that can be detected in both PET and MRI to aid in the interpretation of complex biological processes. This system will be dedicated to the study of small animal model systems at the highest spatial and temporal resolutions attainable. We will build a high resolution, relatively high sensitivity multi-slice muPET scanner integrated within a customized 7T/30cm small animal MR system that will simultaneously record MR and PET images Through the use of fiber-optic couplings, the muPET system will interfere minimally with the muMR system, enabling high quality muPET and IJMRI data to be acquired essentially simultaneously and in near-perfect spatial registration. This system is a natural extension of earlier proof-of-principle systems and a newer prototype animal muPET system now nearing completion. The basic design elements of the system have been tested and demonstrated to work. The combined system we propose adds a number of important features to improve performance and ease of use for in vivo imaging studies. It also incorporates, for the first time, a multi-slice muPET system, with four detector rings simultaneously providing seven imaging planes, spanning an axial field of view of approximately 8mm, with at least 2mm resolution. Simultaneous muPET/muMRI recordings will provide important correlations not available from temporally and spatially separate scans (e.g. BOLD MRI compared with FDG PET). The melded system will provide high resolution anatomical reference systems for muPET studies The 'in register' muMR images will be used to compute scatter and attenuation in the IJPET images and to estimate partial volume errors in the PET scans, thus aiding quantification of the PET signal. This system will open up a number of opportunities not possible with current independent technologies Among them are: Time correlated IJPET and MRS studies of drug distributions; cardiac, CNS and tumor cell metabolism. Simultaneous fMRI and muPET neuroreceptor brain mapping studies in small animals. Validation of new MRI probes using their PET counterparts. Dual PET/MRI labels will allow for "zooming-in" the MRI data collection scheme to those regions of the specimen containing the label, as well as providing for precise registration of the PET & MR images.