STRUCTURAL MRI OUTCOME PREDICTORS IN MCI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 轻度认知功能障碍（MCI）是一种异质性疾病，具有多种病因、表现和结局。这项前瞻性研究将调查基线磁共振成像（MRI）标记物是否可以预测MCI向阿尔茨海默病（AD）的转化。我们认为，内嗅/海马旁、颞下和外侧、后扣带回和楔前灰质萎缩、海马萎缩和侧脑室扩大与3年内向AD的转化密切相关。我们将从已确定的可用受试者中招募90例MCI受试者。他们将接受基线高质量结构MRI扫描和年度临床和神经心理学测试。所提出的用于相应形态显式匹配的最先进的基于表面的算法将减少受试者间的变异性，并增加检测局部疾病影响的能力。该项目的长期目标是影响试验计划和患者选择的方法，并为MCI治疗试验建立一个强有力的替代标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mild cognitive impairment (MCI) is a heterogeneous condition with multiple etiologies, presentations, and outcomes. This prospective study will investigate whether baseline magnetic resonace imaging (MRI) markers can predict conversion of MCI to Alzheimer disease (AD). We propose that entorhinal/parahippocampal, inferior and lateral temporal, posterior cingulate and precuneal gray matter atrophy, hippocampal atrophy and lateral ventricle enlargement will strongly correlate with conversion to AD within 3 years. We will recruit 90 MCI subjects from identified available recources. They will receive a baseline high-quality structural MRI scan and yearly clinical and neuropsychological testing. The proposed state-of-the-art surface-based algorithms for explicit matching of corresponding morphology will reduce intersubject variability, and increase the power to detect localized disease effects. The long-term goal of this project is to influence the methods of trial planning and patient selection, and to establish a powerful surrogate marker for MCI therepeutic trials.