PRR

PRR

• 批准号: 8170638
• 负责人: Jianfei Jiang
• 金额: $ 0.59万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170638
• 关键词: Antiviral Agents; Binding; Biochemical; Complex; Computer Retrieval of Information on Scientific Projects Database; Crystallography; Family member; Funding; Goals; Grant; Immune response; Immune system; Immunologic Receptors; Infection; Institution; Ligand Binding; Ligands; Macromolecular Complexes; Membrane; Pattern recognition receptor; Proteins; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; Toll-like receptors; United States National Institutes of Health; pathogen; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program integrates functional studies with extensive structural analysis of pattern recognition receptors (PRRs) in complex with their ligands as well as downstream adapters and effector molecules. Both membrane-bound (such as the Toll-like receptors) and cytoplasmic (such as the CATERPILLAR family members and RIG-I/MDA5 antiviral proteins) PRRs are targeted. A critical feature of these innate immune receptors is that they distinguish among various classes of pathogen-specific molecules while retaining responsiveness to a large number of related molecules within a given biochemical class. Understanding such "broad" reactivity at the atomic level is one of the primary goals of the program. Ligand binding by the PRRs not only initiates intracellular signaling cascades leading to innate immune responses against infections, but also allows the innate immune system to orchestrate and potentiate the activities of the adaptive immune system. Our research aims to decipher this signaling network by studying structures of macromolecular complexes using x-ray crystallography.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究计划将功能研究与模式识别受体（PRR）及其配体以及下游衔接子和效应分子的广泛结构分析相结合。靶向膜结合（如Toll样受体）和细胞质（如CATERPILLAR家族成员和RIG-I/MDA 5抗病毒蛋白）PRR。这些先天性免疫受体的一个关键特征是，它们区分不同类别的病原体特异性分子，同时保留对给定生化类别内大量相关分子的反应性。在原子水平上理解这种“广泛”的反应性是该计划的主要目标之一。PRR的配体结合不仅启动导致针对感染的先天免疫应答的细胞内信号传导级联，而且还允许先天免疫系统协调和增强适应性免疫系统的活性。我们的研究旨在通过使用x射线晶体学研究大分子复合物的结构来破译这种信号网络。