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IMPAIRED REGULATION OF CYTOCHROMES P450 DURING THE EVOLUTION OF HEPATIC STEATOSIS

IMPAIRED REGULATION OF CYTOCHROMES P450 DURING THE EVOLUTION OF HEPATIC STEATOSIS
肝脂肪变性演变过程中细胞色素 P450 的调节受损
批准号：
nhmrc : 113896
负责人：
Prof Michael Murray
金额：
$12.45万
依托单位：
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2000
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2000-01-01 至 2002-12-31
来源：
https://researchdata.edu.au/impaired-regulation-cytochromes-hepatic-steatosis/76125
关键词：
IMPAIREDREGULATIONCYTOCHROMESP450DURING

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英文摘要
The accumulation of fat in liver is a common problem in early liver injury caused by alcohol, certain drugs and diseases like diabetes. When this occurs the fats can change the amounts of a number of genes and proteins in liver. Cytochrome P450 proteins insert an activated form of oxygen into chemicals, including drugs and fats. In the process, however, some of these activated chemicals can damage surrounding tissues. This project will study the details of how the levels of cytochromes P450 are altered when fat accumulates in liver. The findings may suggest ways in which normal levels of cytochromes P450 can be restored and how to minimise the injurious effects of activated chemicals in liver.
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