Cytochrome P450-mediated epoxides of polyunsaturated fatty acids that regulate cell death and survival

细胞色素 P450 介导的多不饱和脂肪酸环氧化物调节细胞死亡和存活

• 批准号: nhmrc : 570933
• 负责人: Prof Michael Murray
• 金额: $ 33.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytochrome-p450-mediated-death-survival/98900
• 关键词: Cytochrome; P450; mediated; epoxides; polyunsaturated

Omega-3 polyunsaturated fatty acids (PUFAs) decrease cancer risk in man whereas omega-6 PUFA, which are common in western diets, increase risk. In cells cytochrome P450 converts PUFAs to epoxides. Omega-6 epoxides stimulate growth of cells and tumours but we have found that epoxides of the omega-3 eicosapentaenoic acid inhibit cell growth. We will now evaluate the mechanisms of these effects, which could lead to new anticancer treatments, perhaps based on altered diet.

Omega-3多不饱和脂肪酸(PUFA)降低了男性的癌症风险，而西方饮食中常见的omega-6 PUFA则增加了风险。在细胞中，细胞色素P450将多不饱和脂肪酸转化为环氧化物。Omega-6环氧化物促进细胞和肿瘤的生长，但我们发现omega-3二十碳五烯酸的环氧化物抑制细胞生长。我们现在将评估这些作用的机制，这可能导致新的抗癌治疗，可能基于改变饮食。