Cytochrome P450-mediated epoxides of polyunsaturated fatty acids that regulate cell death and survival

Omega-3多不饱和脂肪酸（PUFAs）可以降低男性患癌症的风险，而西方饮食中常见的omega-6多不饱和脂肪酸则会增加患癌症的风险。在细胞中，细胞色素P450将pufa转化为环氧化物。Omega-6环氧化物刺激细胞和肿瘤的生长，但我们发现omega-3二十碳五烯酸的环氧化物抑制细胞生长。我们现在将评估这些影响的机制，这可能会导致新的抗癌治疗，也许是基于改变饮食。

Omega-3 polyunsaturated fatty acids (PUFAs) decrease cancer risk in man whereas omega-6 PUFA, which are common in western diets, increase risk. In cells cytochrome P450 converts PUFAs to epoxides. Omega-6 epoxides stimulate growth of cells and tumours but we have found that epoxides of the omega-3 eicosapentaenoic acid inhibit cell growth. We will now evaluate the mechanisms of these effects, which could lead to new anticancer treatments, perhaps based on altered diet.