STRUCTURAL STUDIES OF HIV-1 REVERSE TRANSCRIPTASE (RT)
STRUCTURAL STUDIES OF HIV-1 REVERSE TRANSCRIPTASE (RT)
批准号:
8170670
负责人:
EDWARD ARNOLD
金额:
$0.32万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30
关键词:
Anti-HIV AgentsComputer Retrieval of Information on Scientific Projects DatabaseCrystallographyFundingGrantHIV-1HIV-1 Reverse TranscriptaseInstitutionLife Cycle StagesMacromolecular ComplexesMethodsNucleic AcidsNucleosidesRNA-Directed DNA PolymeraseResearchResearch PersonnelResistanceResourcesSourceUnited States National Institutes of HealthViruseffective therapyinhibitor/antagonistthree dimensional structure
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
我们将制备HIV-1逆转录酶(RT)与核酸、核苷和非核苷逆转录酶抑制剂的大分子复合体。RT是HIV-1病毒生命周期中的重要组成部分。这些络合物的三维结构将由X射线结晶学方法确定。通过这些研究,我们希望详细了解抑制RT功能的基本原理以及对这些抑制剂的耐药性的出现。最终,我们希望将从我们的结构研究中获得的信息应用于以更好的抗HIV药物的形式推进新的有效治疗策略。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We will prepare macromolecular complexes of HIV-1 reversetranscriptase (RT), an essential component in the life cycle of theHIV-1 virus, with nucleic acid and nucleoside and nonnucleoside reversetranscriptase inhibitors. The three dimensional structures of thesecomplexes will be determined by x-ray crystallographic methods. Throughthese studies we hope to gain a detailed understanding of thefundamental principles underlying inhibition of RT's function and theemergence of resistance to these inhibitors. Ultimately we hope toapply information garnered from our stuctural studies towards theadvancement of new and effective treatment stategies in the form ofbetter anti-HIV drugs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
X-ray Crystallographic Fragment Screening Core
-
批准号:10242904
-
项目类别:
-
资助金额:$36.69万
-
财政年份:2012
-
负责人:EDWARD ARNOLD
-
依托单位:
X-ray Crystallographic Fragment Screening Core
-
批准号:10363021
-
项目类别:
-
资助金额:$39.4万
-
财政年份:2012
-
负责人:EDWARD ARNOLD
-
依托单位:
MACCHESS PROGRAM FOR AUTOMATION AND HIGH-THROUGHPUT
-
批准号:8363513
-
项目类别:
-
资助金额:$6.16万
-
财政年份:2011
-
负责人:EDWARD ARNOLD
-
依托单位:
STRUCTURAL STUDIES OF HIV-1 RT AND RNAP
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批准号:8170617
-
项目类别:
-
资助金额:$0.57万
-
财政年份:2010
-
负责人:EDWARD ARNOLD
-
依托单位:
MACCHESS PROGRAM FOR AUTOMATION AND HIGH-THROUGHPUT
-
批准号:8171485
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项目类别:
-
资助金额:$8.52万
-
财政年份:2010
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV-1 reverse transcriptase structure: function, inhibition, and resistance
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批准号:7750025
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项目类别:
-
资助金额:$76.48万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
MACCHESS PROGRAM FOR AUTOMATION AND HIGH-THROUGHPUT
-
批准号:7955572
-
项目类别:
-
资助金额:$4.15万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
STRUCTURAL STUDIES OF HIV-1 REVERSE TRANSCRIPTASE (RT)
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批准号:7957252
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项目类别:
-
资助金额:$1.95万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV-1 reverse transcriptase structure: function, inhibition, and resistance
-
批准号:8416384
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项目类别:
-
资助金额:$67.66万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIGH RES STRUCT OF HUMAN VIRUSES & VIRAL PROTEINS: SYNCH RADIATION AT CHESS: HIV
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批准号:7955535
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项目类别:
-
资助金额:$3.4万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV-1 reverse transcriptase structure: function, inhibition, and resistance
-
批准号:7916928
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV-1 reverse transcriptase structure: function, inhibition, and resistance
-
批准号:7995227
-
项目类别:
-
资助金额:$74.48万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV-1 reverse transcriptase structure: function, inhibition, and resistance
-
批准号:8213421
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项目类别:
-
资助金额:$72.41万
-
财政年份:2009
-
负责人:EDWARD ARNOLD
-
依托单位:
HIGH RES STRUCT OF HUMAN VIRUSES & VIRAL PROTEINS: SYNCH RADIATION AT CHESS: HIV
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批准号:7721282
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项目类别:
-
资助金额:$12.88万
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财政年份:2008
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV RNase H Natural Product Inhibitors Structural and Computational Biology
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批准号:7640853
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项目类别:
-
资助金额:$43.71万
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财政年份:2008
-
负责人:EDWARD ARNOLD
-
依托单位:
STRUCTURAL STUDIES OF HIV-1 REVERSE TRANSCRIPTASE (RT)
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批准号:7726219
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项目类别:
-
资助金额:$0.34万
-
财政年份:2008
-
负责人:EDWARD ARNOLD
-
依托单位:
STRUCTURAL STUDIES OF HIV-1 REVERSE TRANSCRIPTASE (RT)
-
批准号:7602286
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项目类别:
-
资助金额:$0.6万
-
财政年份:2007
-
负责人:EDWARD ARNOLD
-
依托单位:
HIV RNase H Natural Product Inhibitors Structural and Computational Biology
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批准号:7257662
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项目类别:
-
资助金额:$44.5万
-
财政年份:2007
-
负责人:EDWARD ARNOLD
-
依托单位:
HIGH RES STRUCT OF HUMAN VIRUSES & VIRAL PROTEINS: SYNCH RADIATION AT CHESS: HIV
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批准号:7598528
-
项目类别:
-
资助金额:$12.98万
-
财政年份:2007
-
负责人:EDWARD ARNOLD
-
依托单位:
HIGH RES STRUCT OF HUMAN VIRUSES & VIRAL PROTEINS: SYNCH RADIATION AT CHESS: HIV
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批准号:7357703
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项目类别:
-
资助金额:$19.31万
-
财政年份:2006
-
负责人:EDWARD ARNOLD
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依托单位: