DEVELOPMENT OF MULTI-NUCLEAR COILS FOR BREAST SPECTROSCOPY AT 7T

7T 乳腺光谱学多核线圈的开发

• 批准号: 8171676
• 负责人: DAVID EUHUS
• 金额: $ 2.09万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171676
• 关键词: Axilla; Biological Markers; Brain; Brain Neoplasms; Breast; Chemicals; Choline; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Detection; Development; Diagnosis; Diagnostic; Engineering; Fatty acid glycerol esters; Funding; Glioblastoma; Glioma; Goals; Grant; Human; Image; Institution; Investigation; Learning; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammary Neoplasms; Measures; Medical center; Metabolic; Methods; Mitochondria; Monitor; NMR Spectroscopy; Neoplasm Metastasis; Normal tissue morphology; Nuclear; Pathway interactions; Patients; Phosphorylcholine; Research; Research Personnel; Resolution; Resources; Role; Source; Spectrum Analysis; System; Techniques; Technology; Testing; Texas; Therapeutic; Time; United States National Institutes of Health; Universities; anticancer research; breast lesion; cancer care; cancer risk; clinical care; design; design and construction; in vivo; instrument; lipid metabolism; malignant breast neoplasm; radiofrequency; response; tumor; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent developments in magnetic resonance have the potential to provide much more sensitive and reliable diagnostic information for patients with cancer or at risk for cancer. UT Southwestern Medical Center was fortunate to acquire a 7 Tesla imaging and spectroscopy system in 2007. While the anticipated benefits in terms of spectral sensitivity and resolution in patients have been fulfilled, we learned that acquisition of radiofrequency (r.f.) coils is a critical bottleneck that severely limits the utility of the 7 Tesla instrument in clinical cancer research. The proposed engineering projects at Texas A & M University will target techniques such as parallel imaging and high field spectroscopy that have enormous potential but have not yet transitioned into cancer research or clinical care. We propose the development of non-invasive in vivo human metabolic profiling at 7T. Breast cancer and brain tumors will be the initial targets of our investigation, but these methods are applicable in other cancers. There are three projects: 1. The 7T system will be upgraded and coils will be constructed to optimize imaging and spectroscopy for clinical studies of breast cancer and malignancies involving the brain. Four interrelated subprojects will be accomplished: a) The 7T system will be upgraded to a dual channel 1H transmit system in early 2010. b) Two r.f. coils for spectroscopy of the breast will be designed and constructed at Texas A & M University. Both coils will have the capability of dual channel 1H transmit for 1H imaging and decoupling. One coil will be optimized for 1H decoupling and detection of 31P and the other will be optimized for 1H decoupling and detection of 13C. 31P MRS will be used to study tumor mitochondrial function and phosphocholine concentrations and 13C MRS will be used for tracing fat metabolism and other pathways in cancers. The design criteria will be optimal 13C or 31P spectroscopy integrated with 1H imaging of the unilateral breast. c) One dual channel transmit/receive coil will be constructed for optimized 1H imaging of the breast. The goal is to produce superb 1H images and 1H spectroscopy of the breast and axilla. The coil will be used for breast imaging and spectroscopy of choline, fat content, fat composition of lesions and other metabolites. d) One dual-channel r.f. coil system for 1H imaging and spectroscopy in the brain will be constructed and implemented for research in primary and metastatic brain malignancies. 2. The role of 1H, 13C and 31P NMR spectroscopy in diagnosis of breast lesions and the role of these methods in monitoring therapy will be evaluated. Increased phosphocholine (by 31P NMR) and total choline (by 1H NMR) will be evaluated as biomarkers of small breast lesions and indicators of therapeutic response. The chemical composition of breast tumors will be measured noninvasively by 13C NMR to test whether fat composition or other biomarkers detected by 13C differ in malignant lesions compared to normal tissue. 3. The role of 1H NMR spectroscopy at 7T in management of low grade gliomas, glioblastoma, and metastatic tumors will be evaluated. We will test the hypothesis that for patients with brain tumors, high resolution spectroscopy will identify tumor progression at an earlier time point than currently detectable with standard MR imaging. The intent is to leverage the strengths of Texas A & M University and of UT Southwestern to develop unique technology and to evaluate the role of this technology for cancer care.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 磁共振的最新发展有可能为癌症患者或有癌症风险的患者提供更灵敏和可靠的诊断信息。UT西南医学中心有幸在2007年获得了7特斯拉成像和光谱系统。虽然在患者的频谱灵敏度和分辨率方面的预期益处已经实现，但我们了解到，射频（r.f.）线圈是严重限制7特斯拉仪器在临床癌症研究中的实用性的关键瓶颈。德克萨斯A & M大学拟议的工程项目将针对并行成像和高场光谱等技术，这些技术具有巨大的潜力，但尚未过渡到癌症研究或临床护理。我们建议在7 T下开发非侵入性体内人体代谢谱。乳腺癌和脑肿瘤将是我们研究的最初目标，但这些方法也适用于其他癌症。有三个项目： 1.将升级7 T系统，并构建线圈，以优化乳腺癌和涉及大脑的恶性肿瘤临床研究的成像和光谱学。将完成四个相互关联的子项目：a）7 T系统将在2010年初升级为双通道1H发射系统。B）两个射频用于乳房光谱学的线圈将在德克萨斯A & M大学设计和制造。两个线圈都具有双通道1H发射能力，用于1H成像和去耦。一个线圈将针对1H去耦和31 P检测进行优化，另一个线圈将针对1H去耦和13 C检测进行优化。31 P MRS将用于研究肿瘤线粒体功能和磷酸胆碱浓度，13 C MRS将用于追踪癌症中的脂肪代谢和其他途径。设计标准将是最佳的13 C或31 P光谱与单侧乳房的1H成像相结合。c）将构建一个双通道发射/接收线圈，用于优化乳房的1H成像。目标是产生乳房和腋窝的极好的1H图像和1H光谱。该线圈将用于乳腺成像和胆碱、脂肪含量、病变脂肪成分和其他代谢物的光谱分析。d）一个双通道射频线圈系统的1H成像和光谱在大脑中将被构建和实施的研究在原发性和转移性脑恶性肿瘤。 2. 1H，13 C和31 P NMR波谱在乳腺病变诊断中的作用以及这些方法在监测治疗中的作用将被评估。增加的磷酸胆碱（通过31 P NMR）和总胆碱（通过1H NMR）将作为小乳腺病变的生物标志物和治疗反应的指标进行评价。将通过13 C NMR非侵入性地测量乳腺肿瘤的化学成分，以测试与正常组织相比，通过13 C检测的脂肪成分或其他生物标志物在恶性病变中是否不同。 3.将评价7 T下的1H NMR光谱在低级别胶质瘤、胶质母细胞瘤和转移性肿瘤管理中的作用。我们将检验这样一个假设，即对于脑肿瘤患者，高分辨率光谱将在比目前标准MR成像可检测到的更早的时间点识别肿瘤进展。 其目的是利用德克萨斯A & M大学和UT西南大学的优势，开发独特的技术，并评估该技术在癌症护理中的作用。