MOLECULAR GENETIC BASIS OF MYCOPLASMA ANTIGEN VARIATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 这项USDA ARS合作协议支持密苏里大学哥伦比亚分校的PPAID计划，该计划是由密苏里大学哥伦比亚分校、康涅狄格大学和普拉姆岛动物疾病中心组成的财团的一部分。 相关子项目的总体目标是获得并利用致病性支原体的全基因组序列。真菌属系统发育簇和其他动物支原体，以便了解和干预它们作为引起影响食用动物资源的严重疾病的病原体的作用。 比较基因组和后基因组技术，沿着标准分子方法，被应用于定义和评估这些原核病原体的致病因素、改进的检测、疫苗开发和基础生物学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This USDA ARS cooperative agreement supports the PPAID program at the University of Missouri-Columbia as part of a consortium comprising the University of Missouri-Columbia, the University of Connecticut and the Plum Island Animal Disease Center. The overall objective of the pertinent subproject is to acquire and utilize the complete genomic sequence from pathogenic mycoplasmas of the M. mycoides phylogenetic cluster, and other animal mycoplasmas, in order to understand and intervene in their role as agents causing severe diseases affecting food animal resources. Comparative- and post-genomic technologies, along with standart molecular approaches, are applied to define and evaluate factors contributing to pathogenesis, improved detection, vaccine development and fundamental biology of these prokaryotic pathogens.