MARKEY CENTER FOR STRUCTURAL BIOLOGY, PURDUE UNIVERSITY

普渡大学马基结构生物学中心

• 批准号: 8172019
• 负责人: Barbara Lynn Golden
• 金额: $ 0.36万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172019
• 关键词: Biological Process; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Funding; Goals; Grant; Hour; Institution; Joints; Laboratories; Laboratory Finding; Learning; Photons; Postdoctoral Fellow; Research; Research Personnel; Resources; Science; Source; Students; Synchrotrons; Training; United States National Institutes of Health; Universities; Work; X-Ray Crystallography; base; beamline; graduate student; improved; operation; programs; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Within the Markey Center for Structural Biology at Purdue University, there are nine groups using X-ray crystallography to understand the structural basis of a wide variety of biological processes. As a group, we would like to submit a joint proposal to gain access to the Advanced Photon Source beamlines. The goals of this proposal are to 1) make maximal use of the APS resource and 2) provide training to graduate students and postdoctoral fellows. Crystallographic data collection has become quite rapid, especially at synchrotron sources. As a result, many laboratories, especially the smaller laboratories, find it difficult to completely fill a 24 hour shift at a beamline. To conserve this valuable resource, we submit this program proposal that will allow the groups at Purdue to split shifts at APS. This mode of operation has the added advantage of having students and postdoctoral fellows from various laboratories working together to collect their data. This will facilitate an exchange of information and ideas, and thereby improve the quality of the science and provide an excellent learning opportunity for our student and postdoctoral trainees. Participating PIs in this submission are: Jue Chen, William Cramer, Barbara Golden, Michael Rossmann, Cynthia Stauffacher, Joe Kappock and Dinesh Yernool. Please see attached pdf for descriptions of representative projects and progress from the previous GUP proposal.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在普渡大学马基结构生物学中心，有九个小组使用X射线晶体学来了解各种生物过程的结构基础。作为一个团体，我们希望提交一份联合提案，以获得先进的光子源光束线。该提案的目标是：1）最大限度地利用APS资源，2）为研究生和博士后研究员提供培训。晶体学数据的收集已经变得相当迅速，特别是在同步辐射源。因此，许多实验室，特别是较小的实验室，发现很难完全填满光束线的24小时轮班。为了保护这一宝贵的资源，我们提交了这一计划的建议，将允许在普渡大学的小组分裂在APS轮班。这种运作模式的另一个好处是，来自不同实验室的学生和博士后研究员可以一起收集数据。这将促进信息和思想的交流，从而提高科学的质量，并为我们的学生和博士后学员提供一个很好的学习机会。本次提交的参与PI包括：Jue Chen、William Cramer、Barbara Golden、Michael Rossmann、Cynthia Stauffacher、Joe Kappock和Dinesh Yernool。 请参阅所附的pdf文件，了解代表性项目的说明和先前GUP提案的进展情况。