SIMULATION OF THE MECHANICAL RESPONSE OF RBC MEMBRANE IN LARGE DEFORMATIONS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 红细胞（红血细胞，或RBC）膜，包括脂质双层和主要由肌动蛋白和血影蛋白组成的蛋白质骨架，当细胞在全身循环并通过毛细血管挤压时，通常会发生大的变形。我们调查这种复合膜的机械性能，通过使用多尺度模型，其中包括一个国家的最先进的理解的3D分子结构的骨架，双分子层连接，？流体-结构相互作用，以及应力诱导展开的spectrin的本构律。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The erythrocyte (red blood cell, or RBC) membrane, including a lipid bilayer and a protein skeleton composed mostly of actin and spectrin, is routinely subjected to large deformations as the cell circulates throughout the body and squeezes through capillaries. We investigate the mechanical properties of this composite membrane by using a multi-scale model which incorporates a state-of-the-art understanding of the 3D molecular architecture of the skeleton, the skeleton-bilayer connectivity, the ?uid-structure interaction, and the constitutive law of the spectrin with stress-induced unfolding.