EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 虽然耐力运动员中患有2型糖尿病的受试者之间的肌内脂肪水平是相似的，但与胰岛素抵抗明显无关。在未经训练的受试者中，尤其是2型糖尿病受试者，心肌细胞内脂肪与胰岛素抵抗呈正相关。在耐力运动员中，心肌细胞内脂肪与胰岛素抵抗呈负相关。我们假设，观察到的肌内脂肪与胰岛素抵抗的悖论可以通过肌内脂肪的物理性质的差异来解释。我们建议通过磁共振波谱来测量这些物理性质的差异

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While intramyocellular fat levels are comparable between subjects with type 2 diabetes in endurance athletes, there is a marked disassociation with insulin resistance. In untrained subjects, particularly subjects with type 2 diabetes, there is a positive correlation of intramyocellular fat with insulin resistance. In endurance athletes, there is an inverse correlation of intramyocellular fat with insulin resistance. We hypothesize that the observed paradox of intramyocellular fat with insulin resistance can be explained by differences in the physical properties of the intramyocellular fat. We propose to measure these differences in physical properties by magnetic resonance spectroscopy