EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS

通过 MRS 评估骨骼肌中肌细胞内脂质含量 (IMCL)

• 批准号: 8170471
• 负责人: LISA S CHOW
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170471
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Evaluation; Fatty acid glycerol esters; Funding; Grant; Institution; Insulin Resistance; Lipids; Magnetic Resonance Spectroscopy; Measures; Non-Insulin-Dependent Diabetes Mellitus; Research; Research Personnel; Resources; Skeletal Muscle; Source; United States National Institutes of Health; physical property

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While intramyocellular fat levels are comparable between subjects with type 2 diabetes in endurance athletes, there is a marked disassociation with insulin resistance. In untrained subjects, particularly subjects with type 2 diabetes, there is a positive correlation of intramyocellular fat with insulin resistance. In endurance athletes, there is an inverse correlation of intramyocellular fat with insulin resistance. We hypothesize that the observed paradox of intramyocellular fat with insulin resistance can be explained by differences in the physical properties of the intramyocellular fat. We propose to measure these differences in physical properties by magnetic resonance spectroscopy

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