Training Effects on Skeletal Muscle Lipid Dynamics

训练对骨骼肌脂质动力学的影响

基本信息

  • 批准号:
    8627718
  • 负责人:
  • 金额:
    $ 54.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-01-10 至 2018-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Alteration in skeletal muscle lipid metabolism is thought to significantly contribute to skeletal muscle insulin resistance, which precedes and predicts type 2 diabetes (T2DM). Aerobic training is believed to protect against lipid induced insulin resistance, even in the resting state. Yet, our preliminary data found that insulin sensitivity declines earlier in aerobically trained participants than sedentary participants during modest FFA elevation, suggesting that aerobic training may promote lipid utilization when both glucose and lipid are available. Numerous studies have explained the apparent paradox of high muscle lipid content and high muscle insulin sensitivity in endurance trained humans as a consequence of reduced muscle lipid metabolites, the presumed mediator of lipid induced insulin resistance. However, these studies have only involved static measures and it remains unknown how aerobic training may alter the dynamics of muscle lipid metabolism. This proposal will study the aerobic training effect on lipid metabolism dynamics in sedentary, overweight/obese, insulin resistant humans, who may be particularly susceptible to the effects of IMCL and toxic lipid metabolites accumulation. We will test the hypothesis that aerobic training increases resting muscle lipid metabolism, as measured by markers of IMCL lipolysis, accumulation of lipid metabolites and mitochondrial utilization of fatty acids. In Aim 1, we plan to identify aerobic training effects on markers of skeletal muscle IMCL lipolysis. In Aim 2, we plan to identify aerobic training effects on the dynamics of skeletal muscle lipid metabolites. In Aim 3, we plan to identify aerobic training effects on mitochondrial utilization of fatty acids in skeletal muscle. This study is innovative in its focus on aerobic training associated alterations in skeletal muscle lipid kinetics, particularly in the use of a cutting-edge, stable isotope, pulse-chase design to dynamically examine IMCL accumulation and lipid metabolites. By focusing on sedentary, overweight/obese, insulin resistant subjects, we are studying a population particularly susceptible to dysfunctional skeletal muscle lipid metabolism who may significantly benefit from aerobic training. The significance of this study will be to provide important insights into the mechanistic benefit of aerobic training on skeletal muscle lipid metabolism, opening new directions for treatment of insulin resistance and its consequent complications of T2DM.
项目总结/摘要 骨骼肌脂质代谢的改变被认为是骨骼肌 胰岛素抵抗,是2型糖尿病(T2 DM)的先兆和预测因素。有氧训练被认为可以保护 对抗脂质诱导的胰岛素抵抗,即使在静息状态下。然而,我们的初步数据发现, 在适度FFA期间,有氧训练参与者的敏感性下降早于久坐不动的参与者 升高,这表明有氧训练可能会促进脂肪利用时,葡萄糖和脂质都是 available.许多研究已经解释了高肌肉脂质含量和高脂肪含量之间的明显矛盾。 耐力训练的人的肌肉胰岛素敏感性是由于肌肉脂质代谢物减少, 脂质诱导的胰岛素抵抗的假定介质。然而,这些研究仅涉及静态 然而,有氧训练如何改变肌肉脂质代谢的动力学仍然是未知的。 本研究旨在探讨有氧训练对久坐、不运动者脂代谢动力学的影响, 超重/肥胖、胰岛素抵抗的人,他们可能特别容易受到IMCL的影响, 毒性脂质代谢物蓄积。我们将检验有氧训练增加静息肌肉的假设 脂质代谢,如通过IMCL脂解、脂质代谢物积累和 线粒体利用脂肪酸。 在目标1中,我们计划确定有氧训练对骨骼肌IMCL脂解标志物的影响。在 目的2:研究有氧训练对骨骼肌脂质代谢动力学的影响。在Aim中 3、研究有氧训练对骨骼肌线粒体脂肪酸利用率的影响。 这项研究是创新的,其重点是有氧训练相关的骨骼肌脂质的变化 动力学,特别是在使用先进的,稳定的同位素,脉冲追踪设计,以动态检查 IMCL蓄积和脂质代谢产物。通过关注久坐、超重/肥胖、胰岛素抵抗 受试者,我们正在研究一个特别容易受到骨骼肌脂质功能障碍的人群, 有氧训练对新陈代谢有很大帮助。本研究的意义在于提供 有氧训练对骨骼肌脂质代谢的机械效益的重要见解,开放 治疗胰岛素抵抗及其导致的T2 DM并发症的新方向。

项目成果

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LISA S CHOW其他文献

LISA S CHOW的其他文献

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{{ truncateString('LISA S CHOW', 18)}}的其他基金

Time Restricted Eating As a Viable Alternative to Caloric Restriction for Treating Hyperglycemia in a Population with Type 2 (T2DM) diabetes
时间限制饮食作为热量限制的可行替代方案治疗 2 型 (T2DM) 糖尿病患者的高血糖症
  • 批准号:
    10439148
  • 财政年份:
    2022
  • 资助金额:
    $ 54.56万
  • 项目类别:
Time Restricted Eating As a Viable Alternative to Caloric Restriction for Treating Hyperglycemia in a Population with Type 2 (T2DM) diabetes
时间限制饮食作为热量限制的可行替代方案治疗 2 型 (T2DM) 糖尿病患者的高血糖症
  • 批准号:
    10580820
  • 财政年份:
    2022
  • 资助金额:
    $ 54.56万
  • 项目类别:
Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
长期每日禁食是肥胖高危人群热量限制的可行替代方案
  • 批准号:
    10551991
  • 财政年份:
    2020
  • 资助金额:
    $ 54.56万
  • 项目类别:
Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
长期每日禁食是肥胖高危人群热量限制的可行替代方案
  • 批准号:
    10318213
  • 财政年份:
    2020
  • 资助金额:
    $ 54.56万
  • 项目类别:
Training Effects on Skeletal Muscle Lipid Dynamics
训练对骨骼肌脂质动力学的影响
  • 批准号:
    9203052
  • 财政年份:
    2014
  • 资助金额:
    $ 54.56万
  • 项目类别:
EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS
通过 MRS 评估骨骼肌中肌细胞内脂质含量 (IMCL)
  • 批准号:
    8362866
  • 财政年份:
    2011
  • 资助金额:
    $ 54.56万
  • 项目类别:
EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS
通过 MRS 评估骨骼肌中肌细胞内脂质含量 (IMCL)
  • 批准号:
    8170471
  • 财政年份:
    2010
  • 资助金额:
    $ 54.56万
  • 项目类别:
EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS
通过 MRS 评估骨骼肌中肌细胞内脂质含量 (IMCL)
  • 批准号:
    7955007
  • 财政年份:
    2009
  • 资助金额:
    $ 54.56万
  • 项目类别:
EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT IN SKELETAL MUSCLE BY MAGNETIC RESO
磁共振评价骨骼肌肌细胞内脂质含量
  • 批准号:
    7951751
  • 财政年份:
    2008
  • 资助金额:
    $ 54.56万
  • 项目类别:
Training Grant in Diabetes, Endocrinology and Metabolism
糖尿病、内分泌学和新陈代谢方面的培训补助金
  • 批准号:
    10395483
  • 财政年份:
    1977
  • 资助金额:
    $ 54.56万
  • 项目类别:

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