YOUNG ADULTS WITH ADDICTION: IMPULSIVITY, BRAIN DYSFUNCTION AND RECOVERY

成瘾的年轻人：冲动、脑功能障碍和恢复

• 批准号: 8170438
• 负责人: SHEILA Mary SPECKER
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170438
• 关键词: Abstinence; Admission activity; Age; Amphetamine Abuse; Amphetamine Dependence; Brain; Brain imaging; Brain scan; Cocaine; Computer Retrieval of Information on Scientific Projects Database; Computers; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Gender; Goals; Grant; Impulsivity; Institution; MRI Scans; Measures; Neurobiology; Neurocognition; Neurocognitive; Outcome; Participant; Process; Psychostimulant dependence; Recovery; Recruitment Activity; Research; Research Personnel; Resources; Scanning; Socioeconomic Status; Source; Spectrum Analysis; Testing; Time; United States National Institutes of Health; Variant; Youth; addiction; base; behavior measurement; executive function; gamma-Aminobutyric Acid; neurocognitive test; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will study 15 young adults (ages 18 to 25) who are currently in treatment for cocaine or stimulant dependence at Hazelden Fellowship Club (as well as 15 controls). We will study neurobiological abnormalities, neurocognition and impulsivity particularly as they are associated with the recovery process. Specifically, subjects will undergo neurocognitive testing and tasks measuring impulsivity at two time points: at the beginning of their stay and at approximately 60 days to assess brain recovery through the active process of treatment and abstinence. Both self-rating scales of impulsivity (Barratt Impulsivity Scale) and computer tasks measuring executive functioning will be done. Brain imaging scans would also be completed at these two time points for similar reasons. The brain imaging portion of the study will consist of MRI scans and GABA spectroscopy which will be conducted soon after admission to Fellowship club and at three months. Although the participants would essentially act as their own controls we also would recruit healthy controls matched on age, gender, socioeconomic status and thus would allow comparisons on these tests with normal controls. The same measures and scanning could be done with controls including a repeat scan at three months to measure normal variation in GABA. The goal of this project is to examine whether youth with cocaine or amphetamine dependence (who are in treatment) are more impulsive than controls, as well as to determine the underlying brain abnormalities that exist in people with cocaine or amphetamine abuse as measured by fMRI and GABA spectroscopy. Based on the results of the brain scans, we hope to determine whether brain recovery (e.g. amelioration of abnormalities) occurs in these subjects with addiction over a 2-month period of being in a recovery setting. Through the neurocognitive testing, we hope to determine whether these neurocognitive and behavioral measures of impulsivity are correlated with altered GABA levels. Finally, the researcher will examine if any of the changes observed on behavioral measures or the fMRI are associated with recovery outcomes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目将研究15名年轻人（18至25岁），他们目前正在Hazelden奖学金俱乐部（以及15个对照组）接受可卡因或兴奋剂依赖的治疗。我们将研究神经生物学异常，神经认知和冲动性，尤其是与恢复过程有关。具体而言，受试者将接受神经认知测试和在两个时间点测量冲动性的任务：在他们住宿开始时，在大约60天内，通过主动治疗和戒酒过程来评估大脑恢复。冲动的自我评价量表（Barratt冲动量表）和计算机任务都将完成。出于类似的原因，这两个时间点也将在这两个时间点完成脑成像扫描。 该研究的大脑成像部分将包括MRI扫描和GABA光谱法，该光谱将在入院俱乐部和三个月后不久进行。尽管参与者本质上将充当自己的控制，但我们也将招募与年龄，性别，社会经济状况相匹配的健康对照，因此可以将这些测试与正常对照进行比较。可以通过对照组进行相同的措施和扫描，包括在三个月内重复扫描以测量GABA的正常变异。 该项目的目的是检查可卡因或苯丙胺依赖性（正在接受治疗的人）是否比对照组更冲动，并确定可卡因或苯丙胺滥用者在FMRI和GABA光谱中测量的潜在脑异常。根据脑部扫描的结果，我们希望确定在这些受试者中是否会在恢复环境的2个月内成瘾。通过神经认知测试，我们希望确定这些冲动性的神经认知和行为度量是否与GABA水平改变相关。最后，研究人员将检查有关行为度量或fMRI的任何变化是否与恢复结果相关联。