EARLY MECHANISMS OF HIV TRANSMISSION USING THE SIV/MACAQUE MODEL FOR AIDS
使用艾滋病病毒/猕猴模型研究艾滋病毒传播的早期机制
基本信息
- 批准号:8172686
- 负责人:
- 金额:$ 1.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AIDS VaccinesAccountingAcquired Immunodeficiency SyndromeCD4 Positive T LymphocytesCellsComputer Retrieval of Information on Scientific Projects DatabaseDendritic CellsDevelopmentDissectionEpidemicFundingGenerationsGenital systemGrantHIVHumanImmune responseImmunizationIn SituInfectionInstitutionKnowledgeLymphocyteMacacaMacaca fascicularisMethodsModelingPathway interactionsPhenotypeResearchResearch PersonnelResourcesSIVSexual TransmissionSiteSourceSterilitySurfaceTimeUnited States National Institutes of HealthVaccinesVaginaViralVirus Diseasescell typeintraepithelialmacrophagemucosal sitenovel vaccinespreventrectalsuccesstransmission processvaginal transmission
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Sexual transmission of human immunodeficiency virus (HIV) accounts for the majority of new infections worldwide. A vaccine capable of preventing sexual transmission across genital or rectal mucosal surfaces could provide a method for stopping the AIDS epidemic. The ultimate success of strategies to prevent sexual transmission of HIV depends, in part, on a better understanding of the virological and immunological mechanisms that underlie sexual transmission. Numerous studies have demonstrated the difficulty to achieve sterile protection from vaginally or rectally acquired HIV/SIV using parenteral immunization. Mucosal immunization is seen as the best approach to achieve sustainable immune responses at mucosal sites of viral entry. Defining the mechanisms of vaginal HIV transmission, in particular the initial immune response is central to the development of effective strategies to develop a successful mucosal AIDS vaccine. Our knowledge of the initial target cells involved in mucosal transmission is still evolving. Increasing evidence suggests that the initial site of productive infection occurs in situ at the mucosal surface. Studies of vaginal transmission suggest that the potential initial target cell may be either activated CD4+ T cells or intraepithelial dendritic cells. Precise dissection of viral targets and pathways involved in sexual HIV transmission will prove essential to the global effort to develop a protective vaccine. The identification of initial target cells and the ability to elicit and to enhance cellular or humoral immune responses at mucosal sites is likely to be a crucial step in the development of novel vaccines. These questions are extremely difficult to pursue experimentally in humans. In this study we propose to examine in situ viral infection at mucosal portal of entry in the SIV/cynomolgus (Macaca fascicularis) macaque model using SIV tagged with GFP. Specific aims will include: 1) To identify the types of cells initially infected (i.e., lymphocytes, macrophages, and dendritic cells), their phenotype and function; 2) To investigate the mechanisms, time course, and pathways of viral spread from site of initial infection; and, 3) To explore generation of early mucosal cellular immune response at vaginal site of SIV infection.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marie-Claire Elisabeth Gauduin其他文献
Marie-Claire Elisabeth Gauduin的其他文献
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{{ truncateString('Marie-Claire Elisabeth Gauduin', 18)}}的其他基金
Durable HIV Vaccine Targeting Mucosal Epithelium
针对粘膜上皮的耐用 HIV 疫苗
- 批准号:
10548066 - 财政年份:2022
- 资助金额:
$ 1.92万 - 项目类别:
Durable HIV Vaccine Targeting Mucosal Epithelium
针对粘膜上皮的耐用 HIV 疫苗
- 批准号:
10675701 - 财政年份:2022
- 资助金额:
$ 1.92万 - 项目类别:
A Neonatal Monkey Model of Tuberculosis Vaccination
新生猴结核病疫苗接种模型
- 批准号:
9901954 - 财政年份:2019
- 资助金额:
$ 1.92万 - 项目类别:
A Neonatal Monkey Model for Tuberculosis Vaccination
结核病疫苗接种的新生猴模型
- 批准号:
9201694 - 财政年份:2017
- 资助金额:
$ 1.92万 - 项目类别:
Recombinant Papillomavirus-based HIV Vaccine Targeting Genital Mucosa
针对生殖器粘膜的基于重组乳头瘤病毒的 HIV 疫苗
- 批准号:
8993591 - 财政年份:2015
- 资助金额:
$ 1.92万 - 项目类别:
Trans-complementing papillioma virus for AIDS vaccine
用于艾滋病疫苗的反式互补乳头状瘤病毒
- 批准号:
9011505 - 财政年份:2015
- 资助金额:
$ 1.92万 - 项目类别:
EFFICACY OF A DNA/MVA VACCINE TO PROTECT AGAINST REPEATED VAGINAL SIV CHALLENGE
DNA/MVA 疫苗预防反复阴道 SIV 攻击的功效
- 批准号:
8357926 - 财政年份:2011
- 资助金额:
$ 1.92万 - 项目类别:
EPITHELIAL CELLS AS MUCOSAL ADJUVANT FOR LIFE LONG IMMUNITY
上皮细胞作为终身免疫的粘膜佐剂
- 批准号:
8357687 - 财政年份:2011
- 资助金额:
$ 1.92万 - 项目类别:
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