EXPERIMENTAL MODEL FOR CHORIOAMNIIONITIS AND PRETERM LABOR

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 早产仍然是一个重大的经济和公共卫生负担，发病率正在上升。 我们的目标是建立一个非人灵长类动物（NHP）模型的拉伸诱导早产（PTL），以阐明如何机械拉伸是由子宫肌层和胎膜。 子宫牵拉通常是多胎妊娠中PTL发病的原因，在过去十年中，PTL占早产的15%，占早产率增加的50%。多胎妊娠的妇女可以通过早期超声识别，使其成为预防性干预的理想目标群体。统一的假设是，一种新的NHP模型的子宫拉伸将模仿人类拉伸诱导的PTL，并定义在这种类型的PTL的发病机制的起始和随后的事件。以前，我们已经定义了细胞内机制负责拉伸诱导表达的劳动力相关基因在体外，现在需要建立一个动物模型，在其中测试潜在的治疗干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm birth remains a significant economic and public health burden and the incidence is rising. Our objective is to develop a nonhuman primate (NHP) model of stretch-induced preterm labor (PTL) to elucidate how mechanical stretch is sensed by the myometrium and fetal membranes. Uterine stretch is often responsible for the onset of PTL in multiple gestation, which accounts for 15% of preterm births and 50% of the increase in preterm birth rates over the last decade. Women with a multiple gestation can be identified by early ultrasound making them an ideal group to target for prophylactic interventions. The unifying hypothesis is that a novel NHP model of uterine stretch will emulate human stretch-induced PTL and define the initiating and subsequent events in the pathogenesis of this type of PTL. Previously, we have defined intracellular mechanisms responsible for stretch-induced expression of labor-associated genes in vitro and now need to establish an animal model in which to test potential therapeutic interventions.