MUCOSAL IMMUNITY AND HETEROLOGOUS PROTECTION INDUCED BY SINGLE-CYCLE SIV

单周期 SIV 诱导的粘膜免疫和异源保护

• 批准号: 8172869
• 负责人: David T Evans
• 金额: $ 20.24万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172869
• 关键词: Complement; Computer Retrieval of Information on Scientific Projects Database; Cytoprotection; Funding; Grant; Homing; Immunization; Institution; Intravenous; Macaca mulatta; Mucosal Immunity; Property; Research; Research Personnel; Resources; Route; SIV; Site; Source; T-Lymphocyte; United States National Institutes of Health; Vesicular stomatitis Indiana virus; Virus; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine if the site of immunization influences the mucosal homing properties of virus-specific T cells, and protection against a mucosal challenge, separate groups of rhesus macaques were immunized by intravenous versus subcutaneous routes of inoculation with VSV G trans-complemented single-cycle SIV, and challenged by intrarectal inoculaton with wild-type SIV.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为了确定免疫部位是否影响病毒特异性T细胞的黏膜归巢特性，以及对黏膜攻击的保护作用，将不同组的恒河猴分别通过静脉和皮下接种VSV G反式互补单周期SIV免疫，并用野生型SIV直肠接种。