A NOVEL ASSAY FOR ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

抗体依赖性细胞介导的细胞毒性的新型检测方法

• 批准号: 8357976
• 负责人: David T Evans
• 金额: $ 21.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357976
• 关键词: Antibodies; Biological Assay; Cells; Funding; Grant; Measures; Mediating; National Center for Research Resources; New England; Plasma; Primates; Principal Investigator; Research; Research Infrastructure; Resources; SIV; Source; United States National Institutes of Health; antibody-dependent cell cytotoxicity; base; cost; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We developed a novel assay for measuring antibody titers in plasma capable of mediating antibody-dependent cell-mediated cytotoxicity against simian immunodeficiency virus infected cells.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们开发了一种新的检测血浆抗体效价的方法，该方法能够介导抗体依赖的细胞介导的细胞毒作用，从而对抗猴免疫缺陷病毒感染的细胞。