THE EFFECTS OF AGING IN NONHUMAN PRIMATES

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人类发起有效免疫反应的能力随着年龄的增长而下降，使老年人容易患传染病和癌症。 此外，在年轻人身上测试的疫苗通常对老年人无效。虽然年轻的非人类灵长类动物对于测试普通人群的疫苗功效至关重要，但尚未建立使用老年非人类灵长类动物评估疫苗对老年人的保护作用的模型。因此，与博士合作。 Sue Stacy、Peter Dube (UTHSCSA) 和 Karen Rice (SFBR)，我们评估了年龄对狒狒免疫力的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ability of humans to mount an effective immune response declines with age, leaving the elderly susceptible to infectious diseases and cancer. Moreover, vaccines tested in younger individuals are often ineffective in older people. While young nonhuman primates have been critical in testing vaccine efficacy for the general human population, a model using old nonhuman primates to assess vaccine protection for the elderly has not been established. Thus, in collaboration with Drs. Sue Stacy, Peter Dube (UTHSCSA) and Karen Rice (SFBR), we have assessed the effects of age on immunity in baboons.