THE EFFECTS OF AGING IN NONHUMAN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类发动有效免疫反应的能力随着年龄的增长而下降，这使得老年人容易感染传染病和癌症。此外，在年轻人身上测试的疫苗对老年人往往无效。虽然年轻的非人灵长类动物在测试普通人类群体的疫苗效力方面起到了关键作用，但使用老年非人灵长类动物来评估老年人疫苗保护的模型尚未建立。因此，我们与苏·斯塔西博士、彼得·杜贝博士(UTHSCSA)和凯伦·赖斯博士(SFBR)合作，评估了年龄对狒狒免疫力的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ability of humans to mount an effective immune response declines with age, leaving the elderly susceptible to infectious diseases and cancer. Moreover, vaccines tested in younger individuals are often ineffective in older people. While young nonhuman primates have been critical in testing vaccine efficacy for the general human population, a model using old nonhuman primates to assess vaccine protection for the elderly has not been established. Thus, in collaboration with Drs. Sue Stacy, Peter Dube (UTHSCSA) and Karen Rice (SFBR), we have assessed the effects of age on immunity in baboons.