3D Ultrasound for Pediatric Cardiology

用于儿科心脏病学的 3D 超声

• 批准号: 8249352
• 负责人: Honggang Yu
• 金额: $ 14.16万
• 依托单位: VISIONQUEST BIOMEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-04 至 2013-06-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249352
• 关键词: Algorithms; Appearance; Applications Grants; Area; Cardiac; Cardiology; Carotid Arteries; Child; Childhood; Clinical; Complex; Computer software; Congenital Abnormality; Congenital Heart Defects; Detection; Devices; Diagnosis; Diagnostic; Dimensions; Doctor of Philosophy; Echocardiography; Health Sciences; Heart; Hospitals; Image; Image Analysis; Imagery; Imaging technology; Left ventricular structure; Mainstreaming; Measurement; Modeling; Monitor; New Mexico; Organ; Paper; Pediatric Hospitals; Performance; Phase; Physician Executives; Physicians; Plug-in; Positioning Attribute; Publishing; Reporting; Research; Respiration; Scientist; Screening procedure; Structure; System; Techniques; Technology; Testing; Three-Dimensional Image; Training; Two-Dimensional Echocardiography; Ultrasonography; United States; Universities; Variant; Vision; base; commercialization; congenital heart disorder; cost; disease diagnosis; experience; improved; infant death; interest; reconstruction; tool; two-dimensional

DESCRIPTION (provided by applicant): Vision Quest Biomedical and the University of New Mexico (UNM) Health Science Center have assembled a team of inter-disciplinary scientists with experience in congenital heart disease diagnosis, ultrasound image analysis, and 3D ultrasound reconstruction. This team will develop and test a system to provide 3D multi-view reconstruction for improved 3D image quality and quantitative cardiac function analysis of children hearts using a regular 2D probe. The advantage of this approach is the ability to obtain a full 3D appreciation of cardiac structures and relationships using readily available 2D US systems. Congenital heart defects (CHD) are the most common type of birth defect and present in about 8 of every 1,000 babies born in the United States. CHD is responsible for more deaths in the first year of life than any other birth defect. Our 3D reconstruction technology will give the non- cardiologist physician a tool for early screening and detection of CHD, using more readily available 2D US imaging technology. There are three specific aims to be accomplished in Phase I. The first aim is to improve and validate the automatic algorithm for multi-view 3D reconstruction from 2D freehand echocardiography sequences. The second aim is to collect 2D echocardiography sequences, from 10 subjects and assess performance of registration algorithm for reconstructed 3D volumes. The third aim is to reconstruct the left ventricle for quantitative analysis of cardiac function. The final product is a software plug-in that can be used to render accurate 3D volumes using commercially available 2D ultrasound machines. Our commercialization strategy is to integrate the 3D reconstruction software into an existing commercial ultrasound in Phase II. PUBLIC HEALTH RELEVANCE: Congenital heart defects (CHD) are the most common type of birth defect and present in about 8 of every 1,000 babies born in the United States. CHD is responsible for more deaths in the first year of life than any other birth defect. In this project, we will develop a 3D multi-view reconstruction system to provide improved 3D image quality and quantitative cardiac function analysis of children hearts using a regular 2D probe.

描述(由申请人提供)：Vision Quest Biomedical和新墨西哥大学(UNM)健康科学中心组建了一支跨学科的科学家团队，他们在先天性心脏病诊断、超声图像分析和三维超声重建方面具有经验。该团队将开发和测试一种系统，以提供3D多视角重建，以改善3D图像质量，并使用常规2D探头对儿童心脏进行定量的心功能分析。这种方法的优点是能够使用现成的2D US系统获得心脏结构和关系的完整3D评价。先天性心脏病(CHD)是最常见的出生缺陷类型，在美国出生的婴儿中，每1000人中约有8人患有先天性心脏病。先心病导致的出生第一年的死亡人数比其他任何出生缺陷都要多。我们的3D重建技术将使用更容易获得的2D US成像技术，为非心脏病医生提供早期筛查和检测CHD的工具。第一阶段有三个具体的目标需要完成。第一个目标是改进和验证基于二维徒手超声心动图序列的多视角三维重建的自动算法。第二个目标是收集10名受试者的2D超声心动图序列，并评估重建3D体积的配准算法的性能。第三个目标是重建左心室，以定量分析心功能。最终的产品是一个软件插件，可以使用商业上可用的2D超声机来渲染准确的3D体积。我们的商业化战略是在第二阶段将3D重建软件集成到现有的商业超声中。 与公共卫生相关：先天性心脏病(CHD)是最常见的出生缺陷类型，在美国出生的每1000名婴儿中约有8人患有先天性心脏病。先心病导致的出生第一年的死亡人数比其他任何出生缺陷都要多。在这个项目中，我们将开发一个3D多视图重建系统，以提供改进的3D图像质量和使用常规2D探头对儿童心脏进行定量心功能分析。