Regional & Racial Differences in Hemostasis & Risk of Stroke & Heart Disease

区域性

• 批准号: 8238403
• 负责人: Neil Adrian Zakai
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8238403
• 关键词: ADAMTS; Accounting; Address; Advisory Committees; Anticoagulants; Behavior; Behavioral; Biochemical; Biological; Biological Markers; Biometry; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Classification; Clinical; Coagulation Process; Cohort Studies; Collaborations; Coronary heart disease; Country; Cox Models; Data; Disintegrins; Ensure; Epidemiology; Factor Analysis; Factor VIII; Faculty; Fibrin fragment D; Future; Health; Health behavior; Heart Diseases; Hematology; Hemostatic Agents; Hemostatic function; Incidence; Individual; Ischemic Stroke; Laboratories; Life; Measures; Mediating; Mediation; Mentors; Metalloproteases; Modeling; Neurology; Outcome; Participant; Pathway interactions; Persons; Plasma; Population; Principal Component Analysis; Protein C; Psychosocial Factor; Public Health Schools; Reasons for Geographic And Racial Differences in Stroke; Relative (related person); Research; Research Personnel; Research Training; Risk; Risk Assessment; Risk Factors; Role; Sampling; Socioeconomic Status; Stroke; System; Teleconferences; Training Programs; Translational Research; United States; Universities; Vascular Diseases; Vermont; base; biobank; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular risk factor; career; cohort; design; epidemiologic data; experience; geographic difference; heart disease risk; high risk; lifestyle factors; meetings; member; mortality; novel; psychosocial; public health relevance; racial difference; receptor; regional difference; socioeconomics; von Willebrand Factor

DESCRIPTION (provided by applicant): We propose a 5-year research and training program for Dr. Neil A. Zakai (a junior faculty member at the University of Vermont) to develop an independent career in vascular epidemiology by investigating the impact hemostatic biomarker levels have on regional and racial differences in stroke and coronary heart disease (CHD) in the 30,228 black and white individuals in the REasons for Geographic and Racial Differences in Stroke study (REGARDS). Dr. Mary Cushman, an internationally recognized investigator in cardiovascular epidemiology, will serve as the principle mentor for this project. Though the period of this study, Dr. Cushman will support the educational and research aspects of this project. The advisory committee was selected from experts in epidemiology, neurology, and hematology to provide the best opportunities for networking and future collaborations. Dr. Zakai will meet with the advisory committee both in person and through teleconferences on a monthly basis. To achieve a future independent research career for Dr. Zakai, we propose specific coursework in epidemiology and biostatistics at the University of Vermont and the Johns Hopkins Bloomberg School of Public Health. The project will be a case-cohort study focusing on the impact of multiple hemostatic biomarkers (both individually and in groups) on the regional and racial differences in stroke and CHD incidence in the United States. The specific aims will 1) create the nested case-cohort study within REGARDS, 2) use multivariable modeling and factor analysis to elucidate mechanisms for stroke and CHD and 3) integrate hemostatic biomarkers and traditional CVD risk factors into a model for stroke and CHD risk that can account for racial and/or regional differences in CVD. The Laboratory for Clinical and Biochemical Research at the University of Vermont serves as an ideal setting to conduct this research by bringing together the laboratory aspects and the epidemiological expertise to ensure a rich translational research experience. PUBLIC HEALTH RELEVANCE: There are regional and racial differences in coronary heart disease and stroke not explained by conventional cardiovascular risk factors. We hypothesize that regional and racial differences in hemostasis underlie some of these disparities.

描述（由申请人提供）：我们为 Neil A. Zakai 博士（佛蒙特大学初级教员）提出一项为期 5 年的研究和培训计划，通过调查止血生物标志物水平对中风地理和种族差异研究中的 30,228 名黑人和白人中风和冠心病 (CHD) 的地区和种族差异的影响，发展血管流行病学的独立职业生涯 （问候）。 国际公认的心血管流行病学研究者玛丽·库什曼博士将担任该项目的主要导师。在本研究期间，库什曼博士将支持该项目的教育和研究方面。咨询委员会由流行病学、神经病学和血液学专家组成，为网络和未来合作提供最佳机会。 Zakai 博士将每月亲自或通过电话会议与咨询委员会会面。为了让 Zakai 博士实现未来的独立研究生涯，我们建议在佛蒙特大学和约翰霍普金斯大学彭博公共卫生学院开设流行病学和生物统计学的具体课程。 该项目将是一项病例队列研究，重点关注多种止血生物标志物（单独的和群体的）对美国中风和冠心病发病率的地区和种族差异的影响。具体目标是 1) 在 REGARDS 中创建嵌套病例队列研究，2) 使用多变量模型和因子分析来阐明中风和 CHD 的机制，3) 将止血生物标志物和传统 CVD 风险因素整合到中风和 CHD 风险模型中，该模型可以解释 CVD 的种族和/或地区差异。 佛蒙特大学临床和生化研究实验室将实验室方面和流行病学专业知识结合起来，确保丰富的转化研究经验，是开展这项研究的理想环境。 公共卫生相关性：冠心病和中风存在地区和种族差异，无法用传统的心血管危险因素来解释。我们假设止血方面的地区和种族差异是造成这些差异的原因之一。