权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Core B: Study Design and Molecular Epidemiology Core

核心 B：研究设计和分子流行病学核心

基本信息

批准号：
10447827
负责人：
Neil Adrian Zakai
金额：
$ 29.77万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10447827
关键词：
Address Adult American Heart Association Americas Area Atherosclerosis Award Back Biochemistry Biological Biological Assay Biological Markers Biology Biometry Biostatistical Methods Cardiovascular Diseases Cardiovascular system Cause of Death Centers of Research Excellence Cessation of life Chronic Disease Clinical Clinical Research Clinical Trials Cohort Studies Collaborations Collection Communities Consultations Coronary heart disease Dementia Discipline Disease Educational workshop Elements Ensure Epidemiologic Methods Epidemiologist Epidemiology Evolution Experimental Designs Faculty Fee-for-Service Plans Funding Future Genomics Grant Health Heart Diseases Hematologist Home Impaired cognition Individual Jackson Heart Study Journals Knowledge Laboratories Leadership Mediator of activation protein Mentors Methods Molecular Molecular Epidemiology National Heart, Lung, and Blood Institute Participant Performance Philosophy Population Population Research Program Development Proteomics Public Health Publications Quality Control Reasons for Geographic And Racial Differences in Stroke Reporting Research Research Design Research Personnel Resources Risk Factors Role Sampling Scientist Service delivery model Services South Asian Statistical Data Interpretation Stroke Testing Time Trans-Omics for Precision Medicine Translating Universities Vermont Work assay development biobank brain health cardiovascular health cardiovascular risk factor career complex data cost estimate design disability experience flipped classroom genome sequencing innovation investigator training laboratory experience metabolomics modifiable behavior modifiable risk multi-ethnic multidisciplinary neurovascular novel operation skills success whole genome

项目摘要

PROJECT SUMMARY Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The proposed Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont will address these diseases employing collaborative research. This will be conducted by diverse scientists from multiple disciplines working together to understand the pathobiology and molecular epidemiology of these diseases in order to meet the public health challenges presented by them. The Study Design and Molecular Epidemiology Core (CORE B) of the COBRE will support the evolution of the Center's Project Directors to independent status. It will leverage three decades of experience of the Laboratory for Clinical and Biochemistry Research at the University of Vermont, a leading molecular epidemiology laboratory and home to a biorepository containing ~4.7 million samples from >100,000 research participants from many observational cohort studies and clinical trials. The core will equip the multi- disciplinary Project Directors with the skills they need to conduct their research applying innovative study designs and statistical analyses, and to translate their results from bench or clinical research settings to the population research setting and back, regardless of their prior experience in epidemiology. Our philosophy is that a Core should not only provide service but should train an investigator to be skilled in all of the key elements that the Core provides. Thus, the Core will provide Project Directors with initial and ongoing formal input on their study design and statistical approaches (Aim 1); advise Project Directors on all aspects of biosample procurement, storage, and analysis, including optimizing and troubleshooting assay performance (Aim 2); and support their transition to independence by connecting them with the resources of national studies that will allow them to translate their research to clinical settings (Aim 3). The Core co-directors, Dr. Neil Zakai and Dr. Peter Durda, along with Core biostatisticians, will guide the Project Directors. Dr. Zakai is a hematologist and chronic disease epidemiologist with expertise in many types of study designs, biostatistical approaches to complex data, and laboratory operations, while Dr. Durda has vast experience in molecular laboratory methods and epidemiology. Together, Drs. Zakai and Durda will provide individualized assistance to project directors and innovative workshops utilizing a flipped classroom approach. Services will also be offered to Pilot Grant award recipients who will be supported by institutionally committed funds, to other investigators in the Center's Pipeline development program of potential future Project Directors, and to the UVM research community using a fee-for-service model. Over time the Core will become sustainable, serving the needs of the cardiovascular and neurovascular research community at the University of Vermont.

项目总结