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CD 8 T Cell Mediated Disruption of Blood Brain Tight Junction

CD 8 T Cell Mediated Disruption of Blood Brain Tight Junction
CD 8 T 细胞介导的血脑紧密连接破坏
批准号：
8160750
负责人：
Aaron J Johnson
金额：
$33.44万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-08-01 至 2014-07-31
来源：
https://reporter.nih.gov/project-details/8160750
关键词：
AIDS Dementia ComplexAddressAdoptive TransferAffectAnimalsAreaAstrocytesBiological AssayBiological ModelsBiological PreservationBloodBlood - brain barrier anatomyBlood VesselsBone MarrowBrainBrothersC57BL/6 MouseCD4 Positive T LymphocytesCD8B1 geneCandidate Disease GeneCellsCellular ImmunologyCerebral MalariaCerebrumCessation of lifeChimera organismChromosomes, Human, Pair 3CollaborationsDataDatabasesDiseaseEndothelial CellsGenerationsGenesGeneticGenetic VariationGoalsHematopoieticHourHumanImageImmuneImmune systemIn VitroInflammationInflammation MediatorsInflammatoryInformaticsInterferonsInterleukin-1InterventionKnowledgeLaboratoriesLeadLinkLocationMapsMediatingMicrosatellite RepeatsModelingModificationMolecularMolecular BiologyMonitorMorbidity - disease rateMotorMultiple SclerosisMusNeuraxisNeurologicOther GeneticsPartner in relationshipPathologicPennsylvaniaPeptidesPermeabilityPhenotypePlayPredispositionProcessProtein BiochemistryProteinsQuantitative Trait LociRelative (related person)ResearchResearch PersonnelResistanceResourcesRetroviridaeRoleShockSisterSolidSourceStrokeSymptomsSyndromeSystemT cell responseT-LymphocyteTMEVTechniquesTestingTherapeutic InterventionTight JunctionsTransgenic MiceUniversitiesVascular PermeabilitiesViral Hemorrhagic FeversVirus DiseasesWorkbasecell typechemotherapycongeniccytotoxicdesignexpectationexperiencegenetic analysisgenome wide association studyhuman diseasein vivoinnovationmortalitymouse genomemouse modelnervous system disordernovelnovel therapeuticsperforinpublic health relevancereconstitutionresponseretroviral transductiontherapeutic target

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