Pesticide Interactions in LRRK2 Transgenic Models

LRRK2 转基因模型中农药的相互作用

• 批准号: 8122547
• 负责人: Amy Beatrice Manning-Bog
• 金额: $ 21.31万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122547
• 关键词: Affect; Age; Age of Onset; Aging; Animals; Automobile Driving; Autosomal Dominant Parkinsonism; Behavioral; Brain; Brain region; Calculi; Caspase; Cell Count; Cell Death; Cells; Cleaved cell; Clinical; Cognition; Corpus striatum structure; Development; Diethyldithiocarbamate; Disease; Dopamine; Dopaminergic Cell; Employee Strikes; Environmental Exposure; Etiology; Event; Exhibits; Exposure to; Family; Functional disorder; Gene Mutation; General Population; Goals; Heat shock proteins; Heterogeneity; Human; Impaired cognition; Impairment; Individual; LRRK2 gene; Lead; Leucine-Rich Repeat; Link; Mediating; Mitochondria; Molecular; Motor; Motor Activity; Mus; Mutation; Nerve Degeneration; Neurodegenerative Disorders; Neurotoxins; Outcome; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Pathologic; Pathology; Pathway interactions; Patients; Penetrance; Pesticides; Phenotype; Phosphorylation; Phosphotransferases; Pleomorphism; Post-Translational Protein Processing; Process; Production; Proteins; Protocols documentation; Public Health; Quality Control; Regimen; Reporting; Risk Factors; Role; Smell Perception; Solubility; Substantia nigra structure; Syndrome; Testing; Toxic effect; Toxicant exposure; Transgenic Mice; Transgenic Model; Transgenic Organisms; Ubiquitin; Up-Regulation; age related; aged; base; cytochrome c; disease phenotype; environmental agent; environmental stressor; exposed human population; insight; leucine-rich repeat kinase 2; member; mitochondrial dysfunction; mouse model; mutant; neurofilament; nigrostriatal pathway; novel; overexpression; pesticide exposure; pesticide interaction; protein complex; public health relevance; stress protein; stressor; synuclein; tau Proteins; tau mutation; tau-1; toxicant; trafficking