Transcriptional regulation of CRP1 in smooth muscle

平滑肌中 CRP1 的转录调控

• 批准号: 8153293
• 负责人: Brenda J Lilly
• 金额: $ 9.98万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8153293
• 关键词: Address; Be++ element; Beryllium; Binding Sites; Blood Vessels; Boxing; Cells; Coupled; Data; Development; Disease; Elements; Embryonic Development; Enhancers; Event; Fibroblasts; Gene Activation; Gene Expression; Gene Targeting; Genes; Genetic Transcription; Growth Factor; Indium; Link; Mediating; Molecular; Muscle function; Mutagenesis; Nucleic Acid Regulatory Sequences; Participant; Pathology; Pathway interactions; Phenotype; Regulation; Regulatory Element; Reporter Genes; Research Personnel; Role; Serum Response Factor; Signal Pathway; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Testing; Trans-Activators; Transactivation; Transcriptional Activation; Transcriptional Regulation; Transforming Growth Factor beta; cis acting element; clinically relevant; cysteine rich protein; design; extracellular; human TGFB1 protein; innovation; novel; precursor cell; programs; research study; response; tool; transcription factor

项目成果

Notch3 is critical for proper angiogenesis and mural cell investment.

• DOI: 10.1161/circresaha.110.218271
• 发表时间: 2010-10-01
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Liu H;Zhang W;Kennard S;Caldwell RB;Lilly B
• 通讯作者: Lilly B

Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.

内皮细胞通过旁分泌和 Notch 信号传导下调壁细胞中载脂蛋白 D 的表达。

• DOI: 10.1152/ajpheart.00116.2011
• 发表时间: 2011
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Pajaniappan,Mohanasundari;Glober,NancyK;Kennard,Simone;Liu,Hua;Zhao,Ning;Lilly,Brenda
• 通讯作者: Lilly,Brenda

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.

• DOI: 10.1161/circresaha.108.184846
• 发表时间: 2009-02-27
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Liu H;Kennard S;Lilly B
• 通讯作者: Lilly B

Notch2 and Notch3 function together to regulate vascular smooth muscle development.

• DOI: 10.1371/journal.pone.0037365
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wang Q;Zhao N;Kennard S;Lilly B
• 通讯作者: Lilly B