Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke Tre

溶栓和急性中风治疗 (TAST) 2011：迈向急性中风治疗

• 批准号: 8257015
• 负责人: Gregory J Del Zoppo
• 金额: $ 1.5万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257015
• 关键词: Academia; Academy; Accounting; Acute; Address; Aging; Area; Attention; Award; Basic Science; Benefits and Risks; Blood flow; Brain Injuries; Caring; Cerebrovascular Disorders; Clinic; Clinical; Clinical Management; Clinical Sciences; Clinical Trials; Collaborations; Communities; Congresses; Data; Devices; Diabetes Mellitus; Diagnosis; Discipline; Disease; Educational workshop; Electronics; Evolution; Fees; Fellowship; Fibrinolytic Agents; Fostering; Foundations; Future; General Population; Generations; Goals; Grant; Guidelines; Hypertension; Individual; Industry; Injury; International; Ischemic Stroke; Knowledge; Lead; Learning; Life; Medical; Minority; Mission; Morus; Multimedia; National Institute of Neurological Disorders and Stroke; Neurology; New York; Oral; Patients; Plasminogen Activator; Prevention; Price; Printing; Publications; Recovery; Reporting; Research; Research Personnel; Resolution; Safety; Science; Scientific Advances and Accomplishments; Scientist; Series; Societies; Solutions; Stroke; Symptoms; Systemic disease; Therapeutic; Time; Travel; Universities; Work; abstracting; acute stroke; base; brain tissue; burden of illness; clinical practice; design; discount; evidence base; improved; lectures; literacy; meetings; member; multidisciplinary; nervous system disorder; neurovascular unit; posters; programs; restorative treatment; success; symposium; thrombolysis

DESCRIPTION (provided by applicant): Following ten previous international symposia on the theme of thrombolytic treatment of acute ischemic stroke, The New York Academy of Sciences (NYAS) is hosting the 11th meeting in this series: Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke Treatment in 2021. Organized by Drs. del Zoppo (PI of this grant and co-founder of this series) and Alexandrov, the Scientific Committee, Drs. Marler, Mori, and Kaste, and an International Advisory Board, this three-day conference will be held at NYAS Conference Center in New York, on 1-3 December, 2011. The goals of the symposium are to: (i) provide a neutral forum to a) generate provocative and forward-looking discussions about the state-of-the-art and future directions of research and clinical practice in the acute treatment of ischemic stroke, and b) better understand what the future holds for stroke research and patients ten years for now; (ii) highlight the research contributions of young investigators working in this field; and (iii) develop high-quality print and electronic enduring materials reporting the meeting presentations to the global scientific community. The program will feature keynote and directed plenary lectures, two mini-symposia, and a hands-on workshop, and incorporate plenty of time for networking, and audience and panel discussions. These will lead to vigorous interactions. Speakers will be explicitly asked to respond to a set of questions during their presentations to foster the generation of data-driven, multidisciplinary and focused ideas, explore ischemic stroke as a systemic disease related to other disease entities, and better address the evolution of the brain injury. Highlighted topics include: (i) the neurovascular unit and its injury; (ii) the safety and efficacy of thrombolytic agents currently used or being developed for acute stroke treatment; (iii) new views of the penumbra; (iv) time window considerations and optimized delivery conditions; (v) stabilization of brain tissue for patient recovery; (vi) enhancing the safety of plasminogen activators; (vii) factors that influence risk and benefit; and (viii) alternative approaches. We anticipate wide participation (250-300 attendees) from within and outside the immediate area of cerebrovascular disease, from basic research to clinical settings worldwide. The incorporation of poster and short presentations selected from submitted abstracts into the agenda, and the availability of discounted registration prices and travel fellowships will encourage participation from minority and young investigators. Previous meetings in the US in this series have occurred in La Jolla (1992) and Bethesda (1998), undertaken by the Scripps Clinic and Research Foundation and by the NINDS/ University of Cincinnati, respectively. Given the success in those, the timely and relevant topic, and the scientific rigor of our organizers and advisors, we anticipate a strong turnout to witness these live and enduring discussions, which will foster cross-disciplinary collaborations to promote improved treatment management, new research ideas and directions, and future guidelines for acute treatments of ischemic stroke. PUBLIC HEALTH RELEVANCE: A three-day, scientific conference at the New York Academy of Sciences will provide a neutral forum for clinicians and scientists, experts in cerebrovascular disease and related disorders, to generate provocative and forward-looking discussions to better articulate how clinical and basic science can advance blood flow restorative treatments and medical support in the coming ten to fifteen years, to promote and improve acute treatment of ischemic stroke. The program's cross-disciplinary discussions will approach ischemic stroke as a systemic disease, recognizing the contributions of hypertension, diabetes, and disorders of aging, beyond the conventional targets of time from symptoms onset to deeper understanding of basic mechanisms and the advanced science of clinical trials. This forum will also generate enduring print and online publications to highlight these discussions and make them available to the global scientific community and the general public, foster cross-disciplinary dialogue and collaborations, and promote attention toward the future medical care of stroke patients. 1

描述(由申请者提供)：继之前十次以急性缺血性中风的溶栓治疗为主题的国际研讨会之后，纽约科学院(NYAS)将主办这一系列会议的第11次会议：2011年溶栓与急性中风治疗(TAST)：展望2021年的急性中风治疗。这次为期三天的会议将于2011年12月1日至3日在纽约会议中心举行，由Del Zoppo博士(该基金的PI和该系列的联合创始人)和Alexandrov、科学委员会、Marler、Mori和Kaste博士以及一个国际咨询委员会组织。研讨会的目标是：(I)提供一个中立的论坛，以a)就缺血性中风急性治疗的最新研究和临床实践的最新和未来方向进行挑衅性和前瞻性的讨论，以及b)更好地了解中风研究和患者十年的未来；(Ii)突出在该领域工作的年轻研究人员的研究贡献；以及(Iii)开发向全球科学界报告会议报告的高质量印刷和电子耐久材料。该计划将包括主旨和指导的全体讲座、两个小型研讨会和一个动手研讨会，并包括大量的时间进行网络交流、观众和小组讨论。这些将导致激烈的互动。发言者将被明确要求在他们的演讲中回答一系列问题，以促进数据驱动、多学科和有重点的想法的产生，探索缺血性中风作为一种与其他疾病实体相关的系统性疾病，并更好地解决脑损伤的演变。重点讨论的主题包括：(一)神经血管单位及其损伤；(二)目前用于或正在开发用于急性卒中治疗的溶栓剂的安全性和有效性；(三)半暗带的新观点；(四)时间窗口的考虑和优化的给药条件；(五)稳定患者康复的脑组织；(六)加强纤溶酶原激活剂的安全性；(七)影响风险和益处的因素；(八)替代方法。我们预计将有来自脑血管疾病直接领域内外的广泛参与(250-300名与会者)，从基础研究到世界各地的临床环境。将从提交的摘要中挑选出来的海报和简短介绍纳入议程，以及提供打折的注册费和旅行研究金，将鼓励少数群体和年轻研究人员参与。此前在美国举行的这一系列会议分别在拉霍亚(1992)和贝塞斯达(1998)举行，分别由斯克里普斯临床和研究基金会和NINDS/辛辛那提大学主办。鉴于这些方面的成功，及时和相关的主题，以及我们的组织者和顾问的科学严谨，我们预计将有大量与会者见证这些现场和持久的讨论，这将促进跨学科合作，以促进改善治疗管理、新的研究想法和方向，以及未来缺血性中风急性治疗的指导方针。 公共卫生相关性：在纽约科学院举行的为期三天的科学会议将为临床医生和科学家、脑血管疾病和相关疾病专家提供一个中立的论坛，以产生具有挑衅性和前瞻性的讨论，更好地阐明临床和基础科学如何在未来10至15年内推进血流恢复性治疗和医疗支持，以促进和改善缺血性中风的急性治疗。该计划的跨学科讨论将把缺血性中风作为一种系统性疾病，认识到高血压、糖尿病和衰老障碍的贡献，超越了从症状出现到对基本机制的更深入理解和临床试验的先进科学的传统目标。该论坛还将产生经久不衰的印刷和在线出版物，以突出这些讨论，并向全球科学界和公众提供这些讨论，促进跨学科对话和合作，并促进对中风患者未来医疗保健的关注。1