NAVBO's Workshop on Vascular Matrix Biology and Bioengineering

NAVBO 血管基质生物学和生物工程研讨会

• 批准号: 8130114
• 负责人: THEMIS R KYRIAKIDES
• 金额: $ 2.14万
• 依托单位: NORTH AMERICAN VASCULAR BIOLOGY ORG
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130114
• 关键词: Address; Aneurysm; Area; Atherosclerosis; Attention; Basic Science; Biocompatible Materials; Biology; Biomedical Engineering; Blood Vessels; Calcium; Cardiovascular Diseases; Cardiovascular system; Cells; Chronic Kidney Failure; Clinical; Cods; Communication; Deposition; Development; Devices; Diabetes Mellitus; Discipline; Disease; Drug Formulations; Educational workshop; Elastin; Engineering; Ensure; Extracellular Matrix; Funding; Genetic; Genetic Models; Growth; Growth Factor; Health; Hematological Disease; Hypertension; Immune System Diseases; International; Investigation; Malignant Neoplasms; Massachusetts; Mechanics; Mediating; Metabolic syndrome; Mission; National Heart, Lung, and Blood Institute; Natural regeneration; Organ; Outcome; Pathogenesis; Pathology; Peptide Hydrolases; Play; Postdoctoral Fellow; Prevention strategy; Principal Investigator; Private Sector; Process; Property; Regenerative Medicine; Request for Applications; Research; Research Personnel; Resort; Role; Science; Scientist; Shapes; Signal Transduction; Signaling Molecule; Stroke; Tissue Engineering; Translational Research; angiogenesis; calcification; field study; gain of function; graduate student; human disease; nervous system disorder; novel; product development; programs; receptor; regenerative; repaired; scaffold; stem cell biology; symposium; tool; vascular tissue engineering

DESCRIPTION (provided by applicant): Vascular biology has evolved over the past decade as a major cross-disciplinary field of study which impacts a wide number of major human diseases beyond the more "traditional" vessel wall pathologies, such as atherosclerosis and hypertension. Today, vascular biology also contributes to our understanding of diabetes, metabolic syndrome, chronic kidney disease, neurological disorders, stroke, hematological disorders, cancer and various immunological diseases. More importantly, advances in vascular biology have contributed to the development of many potential new therapies and preventive strategies, in addition to bioengineered devices and engineered replacement organs. However, it has become clear that while our understanding of the role of soluble factors like growth factors has increased greatly, much less attention has been given to the investigation of the extracellular matrix and its microenvironment. Researchers have come to understand that the extracellular matrix plays an active role influencing the pathogenesis of cardiovascular disease, realized by communication between molecules of the extracellular matrix and cells within the blood vessel wall. Furthermore, the vascular extracellular matrix is key to the development of regenerative medicine approaches and vascular tissue engineered products for clinical use. The aim of this one of a kind workshop is to provide a forum for basic and clinical researchers in vascular matrix biology, regenerative medicine, and bioengineering to share their recent and novel science. The workshop will be interdisciplinary, allowing researchers in biology and engineering to come together in a common focus to address important issues in cardiovascular disease and regeneration. The program is characterized by the presentation of cutting edge research in areas like vascular matrix remodeling and repair, matrix genetics and development, stem cell biology, vascular scaffolds, tissue engineering, angiogenesis, matrix genetics and development, regenerative matrices, and the emerging field of vascular matrix calcification. We believe these topics are relevant to the mission of the NHLBI, which is to further our understanding and develop new tools to treat disease. In this application we request funds to partially support this interdisciplinary, international conference which will serve to bring together investigators from the academic and private sectors, post-doctoral fellows, and graduate students from diverse fields of study for four days of intense discussion and study. The conference will be held at the Resort and Conference Center at Hyannis on Cape Cod in Hyannis, Massachusetts from October 16-20, 2011.

描述（由申请人提供）：血管生物学在过去十年中已经发展成为一个主要的跨学科研究领域，其影响了许多主要的人类疾病，而不仅仅是更“传统”的血管壁病理学，如动脉粥样硬化和高血压。今天，血管生物学也有助于我们了解糖尿病，代谢综合征，慢性肾脏疾病，神经系统疾病，中风，血液系统疾病，癌症和各种免疫性疾病。更重要的是，血管生物学的进步促进了许多潜在的新疗法和预防策略的发展，以及生物工程装置和工程替代器官。然而，很明显，虽然我们对可溶性因子如生长因子的作用的理解大大增加，但对细胞外基质及其微环境的研究关注较少。研究人员已经认识到，细胞外基质在影响心血管疾病的发病机制中起着积极的作用，这是通过细胞外基质分子与血管壁内细胞之间的通讯实现的。此外，血管细胞外基质是开发再生医学方法和临床使用的血管组织工程产品的关键。 这个独一无二的研讨会的目的是为血管基质生物学、再生医学和生物工程的基础和临床研究人员提供一个论坛，分享他们最近的新科学。该研讨会将是跨学科的，使生物学和工程学的研究人员能够聚集在一起，共同关注心血管疾病和再生的重要问题。该计划的特点是在诸如血管基质重塑和修复，基质遗传学和发育，干细胞生物学，血管支架，组织工程，血管生成，基质遗传学和发育，再生基质和血管基质钙化的新兴领域的前沿研究的介绍。我们相信这些主题与NHLBI的使命有关，即进一步了解和开发治疗疾病的新工具。 在此申请中，我们要求资金部分支持这一跨学科的国际会议，该会议将汇集来自学术和私营部门的研究人员，博士后研究员和来自不同研究领域的研究生，进行为期四天的激烈讨论和研究。会议将于2011年10月16日至20日在马萨诸塞州海恩尼斯科德角海恩尼斯度假村和会议中心举行。