FASEB SRC on Mitochondrial Assembly & Dynamics in Health, Disease & Aging

FASEB SRC 线粒体组装

• 批准号: 8199803
• 负责人: Antoni Barrientos
• 金额: $ 0.6万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199803
• 关键词: Aging; Aging-Related Process; Applications Grants; Area; Ataxia; Basic Science; Biochemical; Biogenesis; Biology; Blindness; Cardiomyopathies; Charcot-Marie-Tooth Disease; Colorado; Communication; Communities; Complex; Cytoplasm; DNA Maintenance; Defect; Diabetes Mellitus; Diagnostic; Disease; Dystonia; Faculty; Friedreich Ataxia; Functional disorder; Funding; Glean; Goals; Health; Hereditary Spastic Paraplegia; Human; Individual; Inherited; Institutes; Lead; Learning; Leber' s Hereditary Optic Neuropathy; Leigh Disease; Link; Liver diseases; Minority; Mitochondria; Mitochondrial DNA; Mitochondrial Diseases; Mitochondrial Proteins; Molecular; Morphology; Myoclonus; Myopathy; NADH dehydrogenase (ubiquinone); National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Neurodegenerative Disorders; Neuropathy; North America; Nuclear; Oral; Organelles; Outcome; Parkinson Disease; Patients; Physiological Processes; Protein Import; Public Health; Regulation; Research; Research Personnel; Resort; Respiration; Respiratory Chain; Role; Rosemary; Science; Scientist; Seizures; Seminal; Site; Sorting - Cell Movement; Stroke; Structure; Students; Syndrome; Therapeutic; Time; Translational Research; United States National Institutes of Health; Universities; Woman; Work; age related; base; clinical phenotype; cofactor; deafness; design; graduate student; human disease; improved; insight; interest; meetings; mitochondrial dysfunction; nervous system disorder; novel strategies; posters; respiratory; symposium

DESCRIPTION (provided by applicant): This proposal seeks funds to support the 2011 FASEB Research Conference on Mitochondrial Assembly and Dynamics in Health, Disease and Aging. The principal objective is to inaugurate the third FASEB conference on this rapidly expanding area of mitochondrial biology. The meeting will bring together scientists, ranging from established investigators to graduate students, to promote the exchange of scientific ideas among scientists interested in diverse aspects of mitochondrial biology and mitochondrial dysfunction in human disease, with a view to encouraging collaborative approaches and cross-field stimulation. The conference will facilitate discussion of basic and biomedical science as well as for translational research opportunities. Funds are requested to support trainees and junior faculty who would benefit from attendance at this conference. The timing of this conference is significant, as interest in mitochondrial biology and dysfunction has surged. Seminal advances have occurred in recent years on physiological processes within the organelle such as the dynamics of morphology, mitophagy, protein import into sub-compartments, structure of respiratory complex I, and inter-organelle communication. Insight has been gleaned from patients with cardiomyopathy, hepatopathy, and neurodegenerative disease on assembly and regulation. The biochemical defect in most patients results from a defect in assembly and this can lead to a myriad of clinical phenotypes ranging from ataxia, seizures, blindness, myoclonus, dystonia, deafness, and diabetes. Mitochondrial diseases that will be discussed include rare inherited diseases such as Leber's Hereditary Optic Neuropathy (LHON), Leigh's Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia. In addition, the role of mitochondria in general neurodegenerative diseases such as Parkinson's and during the aging process will be discussed in sessions highlighting mitochondrial dynamics and turnover. An understanding of the structure, assembly and function of the mitochondrion is thus a highly significant topic. Sessions will deal with the structure and dynamics of the mitochondrion, the organization of respiratory chain components, transcriptional and translational regulatory circuits controlling mitochondrial biogenesis and function, mitochondrial DNA maintenance, mitochondrial-nuclear and mitochondrial-cytoplasm cross talk, mitochondrial protein sorting, assembly of individual respiratory complexes and cofactor biogenesis. The novelty of this conference lies in the unique focus on mitochondrial biogenesis and the link to mitochondrial disease as well as to common neurodegenerative diseases and the aging process. No other meeting has attempted this. The 2011 FASEB conference is designed to promote the exchange of scientific ideas among scientists interested in diverse aspects of mitochondrial respiration and biogenesis of the respiratory complexes. Interest in mitochondrial biology has surged in recent years, so the topic and timing of this conference are significant in highlighting advances made in mitochondrial dynamics and morphology and ties in well with the NIH Road Map. PUBLIC HEALTH RELEVANCE: The FASEB Conference on Mitochondrial Assembly and Dynamics in Health, Disease and Aging is relevant to public health because the link between mitochondrial diseases, neurodegenerative disorders and the aging process and defects in mitochondrial assembly will be discussed in detail. As an outcome of this meeting, experts in the field of mitochondrial biology will learn more about the molecular basis of mitochondrial diseases such as myopathies and neuropathies and discuss new approaches for improving diagnostics and therapeutics. Experts will also learn about involvement of mitochondrial function/dysfunction in common age-related neurodegenerative disorders and the aging process.

描述（由申请人提供）：该提案寻求资金，以支持2011年FASEB关于健康，疾病和衰老中线粒体组装和动力学的研究会议。主要目的是开创第三届FASEB会议在线粒体生物学这一迅速扩大的领域。会议将汇集从资深研究人员到研究生的科学家，以促进对线粒体生物学和人类疾病中线粒体功能障碍的各个方面感兴趣的科学家之间的科学思想交流，以鼓励协作方法和跨领域激励。会议将促进基础和生物医学科学的讨论以及转化研究的机会。要求提供资金，以支助将从出席这次会议中受益的受训人员和初级教员。这次会议的时机是重要的，因为对线粒体生物学和功能障碍的兴趣激增。近年来，在细胞器内的生理过程，如形态学的动力学，线粒体自噬，蛋白质输入到亚隔室，呼吸复合物I的结构和细胞器间的通信方面取得了重大进展。已经从患有心肌病、肝病和神经退行性疾病的患者中收集到关于组装和调节的见解。大多数患者中的生化缺陷是由组装缺陷引起的，这可导致无数临床表型，包括共济失调、癫痫发作、失明、肌阵挛、肌张力障碍、耳聋和糖尿病。将讨论的线粒体疾病包括罕见的遗传性疾病，如Leber遗传性视神经病变（LHON），Leigh综合征，Charcot-Marie-Tooth综合征，遗传性痉挛性截瘫和Friedreich共济失调。此外，线粒体在一般神经退行性疾病如帕金森氏症和衰老过程中的作用将在强调线粒体动力学和营业额的会议中讨论。因此，了解的结构，组装和功能的微电子是一个非常重要的课题。会议将处理的结构和动力学的呼吸链组件，转录和翻译调控电路控制线粒体的生物发生和功能，线粒体DNA的维护，细胞核和细胞质的串扰，线粒体蛋白分选，组装个别呼吸复合物和辅因子的生物发生。本次会议的新奇之处在于对线粒体生物发生的独特关注以及与线粒体疾病以及常见神经退行性疾病和衰老过程的联系。没有其他会议试图这样做。2011年FASEB会议旨在促进对线粒体呼吸和呼吸复合体生物发生的各个方面感兴趣的科学家之间的科学思想交流。近年来，对线粒体生物学的兴趣激增，因此本次会议的主题和时间对于突出线粒体动力学和形态学的进展以及与NIH路线图的联系具有重要意义。 公共卫生相关性：FASEB关于健康，疾病和衰老中线粒体组装和动力学的会议与公共卫生有关，因为线粒体疾病，神经退行性疾病和衰老过程之间的联系以及线粒体组装缺陷将被详细讨论。作为本次会议的成果，线粒体生物学领域的专家将更多地了解线粒体疾病（如肌病和神经病）的分子基础，并讨论改进诊断和治疗的新方法。专家们还将了解线粒体功能/功能障碍在常见的年龄相关的神经退行性疾病和衰老过程中的参与。