FASEB SRC on The Basic Origins and Medical Consequences of Protein Aggregation

FASEB SRC 关于蛋白质聚集的基本起源和医学后果

• 批准号: 8130003
• 负责人: ANDREW D. MIRANKER
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130003
• 关键词: Adopted; Affect; Alzheimer' s Disease; Amyloid Proteins; Amyloidosis; Animal Model; Area; Basic Science; Beta Cell; Biological Process; Biology; Biophysics; Bovine Spongiform Encephalopathy; Cells; Cessation of life; Chemistry; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Collaborations; Colorado; Competence; Data; Diabetes Mellitus; Diagnostic; Disease; Encephalopathies; Fostering; Goals; Huntington Disease; In Vitro; International; Link; Mediating; Medical; Membrane; Modeling; Molecular Models; Neurodegenerative Disorders; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Organ; Parkinson Disease; Participant; Patients; Physicians; Prion Diseases; Prions; Protein Conformation; Proteins; Request for Proposals; Research; Research Personnel; Role; Schedule; Scientist; Specificity; Structural Biologist; Structural Protein; Structure; System; Technical Expertise; Therapeutic; Time; Toxic effect; Work; base; design; improved; in vivo; interest; lectures; meetings; molecular modeling; posters; prevent; protein aggregate; protein aggregation; protein folding; protein misfolding; protein structure; single molecule; small molecule; symposium; synuclein; three dimensional structure; treatment strategy; working group

DESCRIPTION (provided by applicant): This R13 proposal requests core support for the eighth international FASEB conference on amyloid protein misfolding and disease. The meeting is entitled "The Basic Origins and Medical Consequences of Protein Aggregation", and will be held June 12th to June 17th, 2011 in Snowmass Village, Colorado. The conference will promote personal interaction between approximately 150 participants who are involved in studies concerning protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and type II diabetes. Participants will include chemists, structural biologists, biochemists, cell biologists, researchers who use animal models, and clinicians who treat patients afflicted with amyloid diseases. Although all participants share a common interest in protein misfolding diseases, their diverse backgrounds would prevent many of them from gathering as a group at other meetings. Thus, the conference will provide a unique venue for an interdisciplinary exchange that appears necessary to fully capture all aspects of diseases that are caused by specific aberrant protein structures that, in turn, cause toxicity at the cellular and organ levels. PUBLIC HEALTH RELEVANCE: Proteins perform their biological functions by adopting, or folding, to a precise three dimensional structure. Misfolded proteins can not only lose their function, but can become toxic. This phenomenon is found in a spectrum of diseases that include Alzheimer's, Parkinson's, and type II diabetes. In order to devise diagnostic and treatment strategies, the proposed conference will promote exchange among scientists who study protein structural changes with those that study toxic effects, as well as physician-scientists who treat patients.

描述（由申请人提供）：本R13提案要求为第八届国际FASEB淀粉样蛋白错误折叠和疾病会议提供核心支持。会议的主题是“蛋白质聚集的基本起源和医学后果”，将于2011年6月12日至6月17日在科罗拉多的斯诺马斯村举行。会议将促进大约150名参与蛋白质错误折叠疾病研究的与会者之间的个人互动，这些疾病包括阿尔茨海默氏症、帕金森氏症、亨廷顿氏症和II型糖尿病。与会者将包括化学家，结构生物学家，生物化学家，细胞生物学家，使用动物模型的研究人员，以及治疗淀粉样蛋白疾病患者的临床医生。尽管所有与会者都对蛋白质错误折叠疾病有着共同的兴趣，但他们不同的背景使他们中的许多人无法在其他会议上聚集在一起。因此，会议将为跨学科交流提供一个独特的场所，这似乎是完全捕获由特定异常蛋白质结构引起的疾病的所有方面所必需的，这些异常蛋白质结构反过来会导致细胞和器官水平的毒性。 公共卫生相关性：蛋白质通过采用或折叠成精确的三维结构来执行其生物功能。错误折叠的蛋白质不仅会失去功能，还会变得有毒。这种现象在包括阿尔茨海默氏症、帕金森氏症和II型糖尿病在内的一系列疾病中都有发现。为了制定诊断和治疗策略，拟议的会议将促进研究蛋白质结构变化的科学家与研究毒性作用的科学家以及治疗患者的医生科学家之间的交流。