Pain in Sickle Cell Disease: Basic & Clinical Science Advances and Future Directi

镰状细胞病的疼痛：基本

• 批准号: 8061918
• 负责人: ROBERT E MOLOKIE
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061918
• 关键词: American; Animal Model; Awareness; Basic Science; Clinical Sciences; Collaborations; Communities; Disadvantaged; Discipline; Fostering; Future; Goals; Health; Longevity; Modeling; Nociception; Pain; Pain Research; Patients; Physicians; Research; Research Personnel; Science; Sickle Cell; Sickle Cell Anemia; Site; Societies; chronic pain; meetings; neurobiological mechanism; new technology; painful neuropathy; symposium; translational study

DESCRIPTION (provided by applicant): Pain in patients with sickle cell disease is a well recognized health problem. However, little progress has been made in understanding and treating sickle cell pain. A major barrier is limited opportunities for the interaction and collaboration among researchers from sickle cell disease and pain fields. The purpose of the Symposium, Pain in Sickle Cell Disease: Basic and Clinical Science Advances and Future Directions, is to bring the awareness of the disease and sickle cell pain to pain researchers and physicians, and to illuminate the state-of-science in pain research. The Symposium is planned as a satellite meeting of the 2011 American Pain Society Annual Meeting, so it will bring together sickle cell and pain experts who may otherwise not have an opportunity to have face-to-face dialogue. The symposium will highlight new scientific approaches and new technologies in the scientific community's quest for a better understanding of neurobiological mechanisms and proper treatment of pain in sickle cell disease. The symposium aims to achieve the following specific objective: 1) present the state-of-the-science related to pain in people with sickle cell anemia; 2) recognize the advantages and disadvantages of the different animal models of sickle cell pain; 3) discuss the relevance of advances in pain mechanisms to research in sickle cell pain; 4) recognize potential for sickle cell pain to serve as a translational model of nociceptive and neuropathic pain across the life-span; 5) foster collaborations among sickle cell and pain researchers; and 6) identify potential collaborations for conducting multi-site translational studies. PUBLIC HEALTH RELEVANCE: Limited progress has been made in characterizing and treating chronic pain in sickle cell disease. A major barrier is limited opportunities for the interaction and collaboration among researchers from sickle cell disease and pain fields. The Purpose of the Symposium, Pain in Sickle Cell Disease: Basic and Clinical Science Advances and Future Directions, is to bring the awareness of the disease and sickle cell pain to pain researchers and physicians, and to illuminate the state-of-science in pain research. A major goal of the symposium is to foster potential collaborations among researchers from various disciplines and research centers.

描述（由申请人提供）：镰状细胞病患者的疼痛是一个公认的健康问题。然而，在理解和治疗镰状细胞性疼痛方面进展甚微。一个主要障碍是来自镰状细胞病和疼痛领域的研究人员之间的互动和合作机会有限。研讨会“镰状细胞病疼痛：基础和临床科学进展和未来方向”的目的是让疼痛研究人员和医生认识到该疾病和镰状细胞疼痛，并阐明疼痛研究的科学现状。该研讨会计划作为 2011 年美国疼痛协会年会的卫星会议，因此镰状细胞病和疼痛专家将齐聚一堂，否则他们可能没有机会进行面对面的对话。研讨会将重点介绍科学界寻求更好地了解镰状细胞病的神经生物学机制和适当治疗疼痛的新科学方法和新技术。研讨会旨在实现以下具体目标：1）介绍与镰状细胞性贫血患者疼痛相关的最新科学进展； 2）认识不同镰状细胞痛动物模型的优缺点； 3）讨论疼痛机制的进展与镰状细胞疼痛研究的相关性； 4）认识到镰状细胞痛作为整个生命周期中伤害性疼痛和神经性疼痛的转化模型的潜力； 5) 促进镰状细胞和疼痛研究人员之间的合作； 6) 确定进行多地点转化研究的潜在合作。 公共卫生相关性：在镰状细胞病慢性疼痛的特征和治疗方面取得的进展有限。一个主要障碍是来自镰状细胞病和疼痛领域的研究人员之间的互动和合作机会有限。研讨会的目的是“镰状细胞病疼痛：基础和临床科学进展和未来方向”，旨在提高疼痛研究人员和医生对该疾病和镰状细胞疼痛的认识，并阐明疼痛研究的科学现状。研讨会的一个主要目标是促进来自不同学科和研究中心的研究人员之间的潜在合作。