2011 Signal Transduction Within the Nucleus (Gordon Research Conference)

描述(由申请人提供)：本申请旨在为将于2011年2月27日至3月4日在美国加利福尼亚州文图拉四季酒店举行的第四届戈登研究大会“核内信号转导”提供部分资金。我们之前非常成功的会议分别于2005年2月、2007年3月和2009年3月举行。我们还寻求为将于2013年春季和2015年举行的第五次和第六次会议争取资金承诺。所要求的资金将专门用于支付初级调查员的费用和旅费，这些调查员将出席会议，并以应邀发言、简短演讲或海报的形式介绍他们的工作。这次会议汇集了各种各样的研究人员，他们专注于了解信号通路如何参与核过程的调节。许多酶和大分子机器有助于复杂的解码设备组合，以确保有机体在不断变化的环境中生存。这次会议的独特之处在于，研究脂质信号和质量控制途径的研究人员与研究核功能的研究人员的工作已趋于一致。我们在信号和核过程方面大大扩大了这一计划，远远超过了最初的会议，这些会议侧重于激动剂诱导的核脂和碳水化合物代谢。该程序包括核质信号、核脂信号、染色质结构和修饰、内质网应激途径、核组织和空间结构的作用、核膜动力学和信使核糖核酸生物学。其中许多途径和过程与疾病过程的病理生理学有很好的联系，强调了它们与改善人类健康的关系。例如，生长因子和脂质信号与癌症生物学和衰老的关系；椎板病与早衰(早衰症)的关系；染色质重塑与癌症的关系；细胞因子信号与免疫疾病的关系；以及细胞质量控制/应激途径与肥胖和糖尿病的关系。我们预计，这将是一次杰出而独特的会议，为真正杰出的研究人员提供了交流的机会。所要求的资金将是支持本次会议的关键。 公共卫生相关性：这一应用包括与疾病过程的病理生理学建立相关性的途径和过程的研究，强调它们与改善人类健康的联系。例如：癌症生物学和衰老中的生长因子和脂质信号；椎板病和早衰(早衰症)；干细胞生物学中的染色质重塑和癌症；细胞因子信号和免疫紊乱；细胞质量控制和应激途径及其与肥胖和糖尿病的关系。

DESCRIPTION (provided by applicant): This application seeks partial funding for the fourth assembly of the Gordon Research conference entitled "Signal Transduction Within the Nucleus" to be held February 27- March 4, 2011 at the Four Seasons Hotel, Ventura CA, USA. Our highly successful previous meetings were held February, 2005 March, 2007, and March, 2009. We also seek to secure funding commitment for our fifth and sixth meetings to be held in spring, 2013 and 2015. Requested funds will be used exclusively to support fees and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. This conference brings together a wide variety of investigators focused on understanding how signaling pathways participate in the regulation of nuclear processes. Numerous enzymes and macromolecular machines contribute to the complex ensemble of decoding devices necessary to ensure an organism's survival in ever-changing environments. The uniqueness of this conference is the mixing of investigators studying lipid signaling and quality control pathways with those studying nuclear function whose work has converged. We have significantly broadened this program with respect to both signaling and nuclear processes, well beyond the inaugural conferences which focused on agonist-induced nuclear lipid and carbohydrate metabolism. This program includes nucleo-cytoplasmic signaling, nuclear lipid signaling, chromatin structure and modifications, endoplasmic reticulum stress pathways, roles of nuclear organization and spatial architecture, dynamics of the nuclear envelope, and mRNA biology. Many of these pathways and processes have well-established connections to the patho-physiology of disease processes, underscoring their relationship to improving human health. For example, the relationships of growth factor and lipid signaling to cancer biology and aging; of laminopathies to premature ageing (progeria); of chromatin remodeling to cancer; of cytokine signaling to immunological disorders; and of cellular quality control/stress pathways to obesity and diabetes. We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among truly outstanding investigators. The requested funds will be essential to the support of this conference. PUBLIC HEALTH RELEVANCE: This application includes study of pathways and processes with established relevance to the pathophysiology of disease processes, underscoring their connection to improving human health. Examples include: growth factor and lipid signaling in cancer biology and aging; laminopathies and premature ageing (progeria); chromatin remodeling in stem cell biology and cancer; cytokine signaling and immunological disorders; and cellular quality control and stress pathways and how these relate to obesity and diabetes.