2011 Cilia, Mucus & Mucociliary Interactions Gordon Research Conference

描述（由申请人提供）：本提案寻求部分支持将于2011年2月13日至18日在加州文图拉举行的“纤毛，粘液和粘膜纤毛相互作用”会议。这是继2005年2月、2007年2月和2009年2月成功举办的GRC赞助的同名会议之后，经批准的戈登研究会议（GRC）。本次会议的独特之处在于其对纤毛、黏液和纤毛黏液相互作用的关注。这些领域代表了彼此高度相关的专门科学学科，但很少合并为一个科学会议。近年来，人们越来越认识到这些相互联系在生物学、生理学、功能和疾病方面的科学重要性。在过去的十年里，人们对纤毛的发育、性质和功能的基本认识取得了重大进展；上皮细胞分化；粘蛋白的调节、产生和分泌；粘液的功能和相互作用增加了分子水平上治疗干预的可能性。本次会议上的思想交流是该领域的推动力，主要影响呼吸道疾病，如原发性纤毛运动障碍，囊性纤维化，支气管炎和支气管炎，慢性阻塞性肺疾病，哮喘和慢性鼻窦炎。本次GRC会议是一个论坛，来自不同学科的基础和临床研究人员会面，互动，并将新的基础发现带到转化阶段。总体组织是基于已建立且非常成功的GRC公式。本次会议的目标是：1)汇集纤毛和粘液基本过程学科的世界权威和青年科学家，包括纤毛的组装和功能，上皮细胞的发育和分化，液体和粘膜凝胶中的粘液/粘蛋白功能，粘纤毛粘附和运输原理，以及疾病的相关病理过程；2)提供一个论坛，展示新的研究成果和技术，交流思想，促进基础、转化和临床研究人员之间的新合作；3)整合新知识，将研究人员聚集在一起，使用多种方法，包括结构和数学建模、生物工程、成像和计算遗传学；4)通过合理的会议规划和组织，确保女性、少数民族和年轻研究人员（初级教师、研究员、博士前和博士后学生）的充分代表性。会议以纤毛、黏液和纤毛黏液相互作用的前景和主题演讲开场。它继续举行关于纤毛和粘膜成分发育的会议；信号传导和转录调控；粘液和纤毛的基本过程；了解黏毛纤毛疾病的遗传学方法；纤毛、粘液和纤毛黏液相互作用疾病；纤毛和黏液的结构-功能关系黏膜纤毛的交互;和界面上的生命：纤毛和流体的相互作用。

DESCRIPTION (provided by applicant): This proposal seeks partial support for a conference on "Cilia, Mucus and Mucociliary interactions" to be held in Ventura, CA from February 13 to 18, 2011. This is an approved Gordon Research Conference (GRC) following successful GRC-sponsored conferences of the same title held in February 2005, 2007, and 2009. This conference is unique in its focus on cilia, mucus and mucociliary interactions. These fields represent specialized scientific disciplines that are highly relevant to each other, yet are rarely combined into a single scientific conference. The scientific importance of these interconnections with respect to biology, physiology, function and disease has been increasingly recognized in recent years. The past decade has seen major advances in the basic understanding of ciliary development, properties and function; epithelial cell differentiation; mucin regulation, production and secretion; and mucus functions and interactions that have increased possibilities for therapeutic intervention at the molecular level. The exchange of ideas at this conference is a driving force for this field that impacts primarily on diseases of the respiratory tract, e.g. primary ciliary dyskinesia, cystic fibrosis, bronchitis and bronchorrhea, chronic obstructive pulmonary diseases, asthma and chronic rhinosinusitis. This GRC conference is a forum where basic and clinical researchers from diverse disciplines meet, interact, and bring new basic findings to the translational stage. The general organization is based on the established and very successful GRC formula. The objectives of this conference are: 1) To bring together world authorities and young scientists in the disciplines of fundamental process in cilia and mucus including ciliary assembly and function, epithelial cell development and differentiation, mucus/mucin function in fluids and mucosal gels, principles of mucociliary adhesion and transport, and related pathologic processes in diseases; 2) To provide a forum for presentation of new research findings and technologies, exchange of ideas, and the stimulation of new collaborations among basic, translational, and clinical researchers; 3) To integrate new knowledge by bringing together investigators using a diverse range of approaches including structural and mathematical modeling, bioengineering, imaging and computational genetics; and 4) To assure strong representation of women, minorities, and young investigators (junior faculty, fellows, predoctoral and post-doctoral students) through sound planning and organization of the meeting. The conference opens with presentations of Prospects and Themes for cilia, mucus, and mucociliary interactions. It continues with sessions on Development of ciliary and mucous components; Signaling and transcriptional control; Fundamental processes in mucus and cilia; Genetic approaches to understanding mucociliary diseases; Diseases of cilia, mucus, and mucociliary interactions; Structure-function relationships in cilia and mucus; Mucociliary interactions; and Life at the interface: cilia and fluid interactions. PUBLIC HEALTH RELEVANCE: The mucociliary system is one of the primary defense mechanisms of mammalian respiratory tracts, as mucus traps air-borne pathogens and toxins and the coordinated beating of cilia in the underlying fluid layer drives the mucus layer upward so that it can be swallowed. However, abnormalities in either quantity or physicochemical properties of the mucus produced by cells of the respiratory tract, or genetic defects in ciliary assembly or structure, leads to airway obstruction by mucus and resultant respiratory tract diseases. This conference brings together experts on cilia, mucus, and mucociliary interactions to update progress in these areas and stimulate new approaches to better understanding their impact on health and diseases.