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Functional Consequences of O2 Carrying Transfusion Toxicity

携带氧气的输血毒性的功能性后果

基本信息

批准号：
8396972
负责人：
Marcos Intaglietta
金额：
$ 51.38万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8396972
关键词：
Acute Affect Allogenic Animal Model Autologous Awareness Binding Biochemical Biological Availability Biological Markers Blood Blood Circulation Blood Substitutes Blood Transfusion Blood Vessels Blood capillaries Blood flow Cardiovascular system Cell Survival Cells Characteristics Chemicals Cholesterol Chronic Databases Development Diabetes Mellitus Diet Disease Dorsal Encapsulated Engineering Event Experimental Models Exposure to Extravasation Functional disorder Globin Goals Hamsters Haptoglobins Hemoglobin Hemolysis Hemorrhagic Shock Human Hypertension Incidence Inflammation Inflammatory Ischemia Knowledge Lesion Link Long-Term Effects Measurement Measures Mediating Medicine Methods Microcirculation Modeling Molecular Molecular Probes Obesity Optics Organ Outcome Oxidative Stress Oxygen Parasites Parasitic Diseases Pathology Pathway interactions Perfusion Physiological Physiological Processes Plasma Population Process Property Recombinants Reperfusion Therapy Resuscitation Rheology Severities Stress Technology Therapeutic Time Tissues Tourniquets Toxic effect Transfusion Trauma analytical method base capillary density experience in vivo intravital microscopy nanoparticle polymerization response shear stress tool

项目摘要

We aim to understand the toxicifies associated with the acellular hemoglobin (Hb) in the circulation by applying in vivo microvascular tools and methods. Our results will expand the knowledge and therapeutic alternatives to hemolyfic pathologies, blood transfusions and Hb-based oxygen carriers (HBOCs). Toxicity will be analyzed in terms of microcirculatory phenomena measured by quantifying changes in funcfional capillary density (FCD) in a hamster window chamber model. FCD is a general functional biomarker that integrates systemic, cardiovascular, cellular, and biochemical changes resulfing from Hb-based transfusions. We will use Hbs generated by recombinant technology and chemical modificafions that emphasize each of the properties that leads to a

我们的目标是通过应用了解与循环中无细胞血红蛋白 (Hb) 相关的毒性体内微血管工具和方法。我们的结果将扩大知识和治疗替代方案溶血性病变、输血和血红蛋白载氧体 (HBOC)。毒性分析将在通过量化功能性毛细血管密度（FCD）的变化来测量微循环现象仓鼠窗室模型。 FCD 是一种通用功能生物标志物，整合了系统、基于血红蛋白的输血引起心血管、细胞和生化变化。我们将使用 Hbs 通过重组技术和化学修饰产生，强调了每一个特性导致