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Functional Consequences of O2 Carrying Transfusion Toxicity

Functional Consequences of O2 Carrying Transfusion Toxicity
携带氧气的输血毒性的功能性后果
批准号：
8396972
负责人：
Marcos Intaglietta
金额：
$51.38万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-08-01 至 2017-07-31
来源：
https://reporter.nih.gov/project-details/8396972
关键词：
AcuteAffectAllogenicAnimal ModelAutologousAwarenessBindingBiochemicalBiological AvailabilityBiological MarkersBloodBlood CirculationBlood SubstitutesBlood TransfusionBlood VesselsBlood capillariesBlood flowCardiovascular systemCell SurvivalCellsCharacteristicsChemicalsCholesterolChronicDatabasesDevelopmentDiabetes MellitusDietDiseaseDorsalEncapsulatedEngineeringEventExperimental ModelsExposure toExtravasationFunctional disorderGlobinGoalsHamstersHaptoglobinsHemoglobinHemolysisHemorrhagic ShockHumanHypertensionIncidenceInflammationInflammatoryIschemiaKnowledgeLesionLinkLong-Term EffectsMeasurementMeasuresMediatingMedicineMethodsMicrocirculationModelingMolecularMolecular ProbesObesityOpticsOrganOutcomeOxidative StressOxygenParasitesParasitic DiseasesPathologyPathway interactionsPerfusionPhysiologicalPhysiological ProcessesPlasmaPopulationProcessPropertyRecombinantsReperfusion TherapyResuscitationRheologySeveritiesStressTechnologyTherapeuticTimeTissuesTourniquetsToxic effectTransfusionTraumaanalytical methodbasecapillarydensityexperiencein vivointravital microscopynanoparticlepolymerizationresponseshear stresstool

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We aim to understand the toxicifies associated with the acellular hemoglobin (Hb) in the circulation by applying in vivo microvascular tools and methods. Our results will expand the knowledge and therapeutic alternatives to hemolyfic pathologies, blood transfusions and Hb-based oxygen carriers (HBOCs). Toxicity will be analyzed in terms of microcirculatory phenomena measured by quantifying changes in funcfional capillary density (FCD) in a hamster window chamber model. FCD is a general functional biomarker that integrates systemic, cardiovascular, cellular, and biochemical changes resulfing from Hb-based transfusions. We will use Hbs generated by recombinant technology and chemical modificafions that emphasize each of the properties that leads to a
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