2012 Endothelial Cell Phenotypes in Health & Disease GRC/GRS

描述(由申请人提供)：内皮细胞和血管系统的改变在从心血管疾病到糖尿病再到癌症的广泛疾病的发病机制中发挥着核心作用。对内皮细胞生物学的研究对理解内皮功能障碍是如何影响人类健康和疾病做出了巨大贡献。内皮细胞生物学领域提供了无与伦比的合作机会，科学家之间的跨学科互动以及跨学科和多学科的研究培训。这是对第四届两年一度的戈登研究会议和伴随而来的关于健康和疾病中的内皮细胞表型的戈登研究研讨会的部分支持的申请。会议将于7月29日至8月3日在托斯卡纳的Il Ciocco举行。这笔赠款的资金将专门用于支付注册费和参加会议的旅费。 供15名实习生和6名年轻调查人员使用。这次GRC将汇集来自对内皮细胞有共同兴趣的不同学科的领先研究人员，提供正在推动该领域的新见解和新视角。本次会议将重点介绍与内皮细胞生物学相关的最新发现，重点是内皮细胞类型的异质性和基础生物学向临床的转化。会议的目标是促进与内皮细胞生物学相关的新的合作和研究方向，并通过为初级科学家提供与该领域的领先研究人员互动、发展关系和学习的机会来促进他们的发展。这次会议以前促进了科学小组之间新的跨学科合作，并由于会议期间和会议后发生的协同互动而刺激了更快的进展和发现。此外，在本次会议的历史上，将第一次由博士后级别的初级研究人员组织会议前戈登研究研讨会。研讨会期间的活动将面向初级研究人员，旨在：(1)向他们提供关于内皮细胞在发育、健康和疾病方面的基本背景，以最大限度地提高他们对科学的理解，这将在随后的会议上讨论；(2)从该领域的同行和专家那里获得对他们正在进行的研究项目的反馈；以及(3)促进他们与该科学社区的高级成员的互动，以促进该领域的初级和高级研究人员之间的网络联系。2012年大会的主席和副主席将由苏珊·E·夸金和阿南斯·卡鲁曼奇担任，他们都是内科科学家，也是内皮细胞生物学领域公认的领导者。该计划包括9场会议和3场主旨演讲。会议是基于一般主题开发的，将跨越多个学科，提供对基本机制及其在临床中的应用的见解，并旨在跨越传统界限。有29位受邀演讲者，其中包括9位女性。将从提交的摘要中选出两个简短的演讲和5个最佳海报奖，并将包括妇女、年轻调查人员和代表性不足群体的成员参加。公共卫生相关性：内皮细胞和血管系统为健康中的所有组织提供维持生命的营养物质，是一系列疾病的中心组成部分，包括糖尿病并发症、癌症和视网膜疾病的发展和进展、类风湿性关节炎、肺、肾脏和心血管疾病等炎症条件。排列在健康血管或病变血管系统中的内皮细胞具有一些基本特征，但表现出独特的特性。了解这种异质性，是开发特定的、有针对性的疗法来治疗一些毁灭性疾病的手段，并已在眼病和肿瘤领域被证明是成功的。

DESCRIPTION (provided by applicant): Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of diseases from cardiovascular disease to diabetes to cancer. Research into the biology of the endothelium has contributed greatly to understanding how endothelial dysfunction underlies human health and disease. The field of endothelial cell biology provides unparalleled opportunities for collaboration, cross discipline interaction among scientists and interdisciplinary and multidisciplinary research training. This is an application for partial support of the 4th biennial Gordon Research Conference and accompanying Gordon Research Seminar on Endothelial Cell Phenotypes in Health and Disease. The conference will be held July 29 - Aug 3 in Il Ciocco, Tuscany. Funds from this grant will be used exclusively to support registration fees, and travel to the conference for 15 trainees and 6 young investigators. This GRC will bring together leading researchers from a variety of disciplines with shared interest in the endothelium, providing new insights and perspectives that are moving the field. This meeting will highlight the latest discoveries related to endothelial cell biology with an emphasis on heterogeneity of endothelial cell types and translation of basic biology to the clinic. The goal of the meeting is to promote new collaborations and research directions related to endothelial cell biology and to foster the development of junior scientists by offering them the chance to interact with, develop relationships and learn from the leading researchers in the field. This conference has previously fostered new cross- discipline collaborations among scientific groups and has stimulated more rapid advances and discoveries because of synergistic interactions that occurred during and after the meeting. In addition, for the first time in the history of this conference, a pre-conferece Gordon Research Seminar will be organized by junior investigators at the postdoctoral level. Activities during the Seminar will be oriented to junior investigators and are intended to: (1) provide them with the basic background on endothelial cells in development, health, and disease necessary to maximize their understanding of the science which will be discussed in the subsequent conference, (2) receive feedback on their ongoing research projects form peers and experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote networking between junior and more senior researchers in the field. The Chair and Vice Chair of the 2012 conference will be Susan E. Quaggin and Ananth Karumanchi, both physician-scientists and recognized leaders in endothelial cell biology. The program consists of 9 sessions and 3 keynote addresses. Sessions were developed based on general themes and will cross disciplines, providing insights from basic mechanisms and their applications in the clinic and designed to span traditional boundaries. There are 29 invited speakers including 9 women. Two short talks and 5 best poster awards will be selected from submitted abstracts for presentation and will include a balance of women, young investigators and members of underrepresented groups to participate. PUBLIC HEALTH RELEVANCE: Endothelial cells and the vasculature provide life sustaining nutrients to all tissues in health an are central components of a broad spectrum of diseases including the complications of diabetes, development and progression of cancer and retinal diseases, inflammatory conditions such as rheumatoid arthritis, pulmonary, kidney and cardiovascular disease. The endothelial cells that line healthy blood vessels or diseased vasculature share some fundamental traits but exhibit unique properties. Understanding this heterogeneity, is the means to develop specific, targeted therapies to treat a number of devastating diseases and has proved successful in the arena of eye disease and tumors.