The 18th Hemoglobin Switching Conference

第18届血红蛋白转换会议

• 批准号: 8319727
• 负责人: James Douglas Engel
• 金额: $ 2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319727
• 关键词: American Society of Hematology; Back; Biochemical; Biochemistry; Cell Differentiation process; Cells; Cellular biology; Clinical; Collaborations; Complementary DNA; Development; Developmental Biology; Disease; Erythrocytes; Erythropoietin; Etiology; Europe; Faculty; Fertilization; Gene Expression Regulation; Genetic; Genomics; Globin; Hematology; Hematopoietic; Hemoglobin; Hemoglobinopathies; Human; Human Cloning; Inherited; International; Lung; Metabolic Diseases; Metabolism; Minority; Molecular; Molecular Biology; Mutation; Oxygen; Physicians; Physiology; Postdoctoral Fellow; Process; Research; Research Personnel; Science; Scientist; Seeds; Site; Structure; Students; Tissues; Waste Products; Woman; Work; career; disease characteristic; effective therapy; meetings; novel; peer; success; symposium

DESCRIPTION (provided by applicant): The biannual Hemoglobin Switching Conference has been ongoing for 31 years, and there are multiple reasons for its resounding success. First and foremost, the organizers (Stamatoyannopoulos, Higgs and Engel) strive to identify and then highlight new discoveries by always including new investigators and studies that impinge on the process of hemoglobin switching. Second, this is the only venue (other than the annual ASH meeting, with > 14,000 attendees) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, hemoglobinopathies. Third, the meetings have historically morphed into focusing on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin, but it has also launched the careers of many of the current leaders in this field (indeed, numerous postdoctoral fellows and young faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the bi- annual alternation in site between the U.S. and Europe. In 2012 the Conference will again be held at the Asilomar Conference Center in Monterrey, CA, because of both international accessibility and economy. PUBLIC HEALTH RELEVANCE: The most commonly inherited human disorders are hemoglobinopathies, diseases that disrupt the function of the red blood cells that carry oxygen to tissues to execute basic metabolism and that also carry waste products back to the lungs for exchange for fresh oxygen. We now understand a great deal about the origins of these metabolic diseases from a genetic and biochemical perspective, but we are only beginning to understand how we might devise effective therapies to treat them. This international conference, held every two years alternating between Europe and the U.S., is the only meeting of its kind, and provides a forum for sharing information between molecular and cell biologists who study disease characteristics and etiology and their clinical counterparts who treat these diseases. This conference is consciously more inclusive of young people, women and minority participation than any other forum.

描述（由申请人提供）：每年一次的血红蛋白切换会议已经进行了31年，并且有多种原因带来了成功。首先，组织者（Stamatoyannopoulos，Higgs和Engel）努力识别，然后通过包括新的研究人员和研究对血红蛋白转换过程的研究来突出新发现。其次，这是唯一一个召集基础科学家和临床医生来讨论血红蛋白病的分子和发育起源和治疗方法的唯一场所（与14,000名参与者的年度灰分会议之外）。第三，历史上的会议已经变成了专注于科学所在的任何地方，因此仍然是极其局部的，不仅是展示第一个cDNA克隆的论坛，第一个克隆的人类基因组基因座（以及同一基因组中的第一个突变）（以及第一个突变），以及erythropoietin的结构，而且是eriythropoietin的结构，而且还启动了许多领导者的职业生涯（这确实是许多职业生涯，而且还源于许多职业生涯，而且在许多领域的职业生涯中，而且在许多领域的职业生涯中，而且在许多领域的职业生涯，并且在许多领域的职业生涯，并且在许多领域的职业生涯，并且在许多领域中均在许多领域的职业生涯，并且在许多领域中均在许多领域的职业生涯，并且在许多领域的职业生涯，并且是许多领域的职业生涯（全体会议在这次会议上）。第四，这是有关该主题的唯一会议，通常在美国内部和外部的调查人员参加大约同等的出勤率，这一事实反映了美国和欧洲之间的年度交替。 2012年，由于国际可及性和经济性，该会议将再次在加利福尼亚州蒙特雷的Asilomar会议中心举行。 公共卫生相关性：最常见的人类疾病是血红蛋白疾病，疾病破坏了将氧气携带到组织的红细胞功能以执行碱性代谢的功能，并且还将废物产物带回肺部以换取新鲜氧气。现在，我们从遗传和生化的角度了解了这些代谢疾病的起源很多，但是我们才开始了解如何设计有效的治疗疗法来治疗它们。这次国际会议每两年举行一次欧洲与美国之间的交替举行，是同类唯一的会议，并为研究疾病特征和病因的分子和细胞生物学家之间的信息提供了一个论坛，以及治疗这些疾病的临床对应物。这次会议比其他任何论坛都更有意识地包括年轻人，妇女和少数派的参与。