20th Hemoglobin Switching Conference

摘要 两年一度的血红蛋白转换大会已经持续了39年，有 它取得巨大成功的原因有很多。首先，组织者(Stamatoyannopoulos， 希格斯和恩格尔)总是努力发现并突出新发现，包括新的、年轻的 影响珠蛋白生物合成过程的调查和研究。第二，这是唯一的 会场(年度ASH会议除外，与会者超过14,000人) 基础科学家和临床医生讨论分子和发育起源，以及 治疗人类最常见的遗传性疾病--血红蛋白病。第三， 从历史上看，会议一直高度关注科学的发展方向，因此 非常热门，而且不仅是展示第一个cdna克隆的论坛，第一个克隆的 人类基因组基因座(及其首次突变)、促红细胞生成素的结构和 发现了GATA和KLF转录因子家族，但它也开启了 目前这一领域的许多领导者(确实，首先是许多博士后研究员和年轻教员 在本次会议的全体会议上介绍了他们的工作)。第四，这是唯一一次关于这个问题的会议 通常来自内部和外部调查人员的出席率大致相同的话题 美国，这一事实反映在美国和欧洲之间每两年一次的场地轮换中。在……里面 2016年大会将第三次在加利福尼亚州的阿西洛玛会议中心举行， 这既是因为国际交通便利，也是因为经济。

Abstract The biennial Hemoglobin Switching Conference has been ongoing for 39 years, and there are multiple reasons for its resounding success. First and foremost, the organizers (Stamatoyannopoulos, Higgs and Engel) strive to identify and then highlight new discoveries by always including new, young investigators and studies that impinge on the process of globin biosynthesis. Second, this is the only venue (other than the annual ASH meeting, with more than 14,000 participants) that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of, and treatments for, the hemoglobinopathies, the most common inherited diseases in man. Third, the meetings have historically evolved with intense focus on wherever the science led, thus remaining extremely topical, and has not only been the forum for presenting the first cDNA clones, the first cloned human genomic locus (and the first mutations in same), the structure of erythropoietin and the discovery of the GATA and KLF transcription factor families, but it has also launched the careers of many of the current leaders in this field (indeed, numerous postdoctoral fellows and young faculty first presented their work in plenary sessions at this conference). Fourth, this is the only meeting on this topic that routinely has approximately equal attendance by investigators from both inside and outside the U.S., and this fact is reflected by the biennial alternation in site between the U.S. and Europe. In 2016 the Conference will be held for the third time at the Asilomar Conference Center in California, because of both the ease of international accessibility and economy.